Nam Sungmin, Mooney David
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02134, United States.
Wyss Institute for Biologically Inspired Engineering, Cambridge, Massachusetts 02115, United States.
Chem Rev. 2021 Sep 22;121(18):11336-11384. doi: 10.1021/acs.chemrev.0c00798. Epub 2021 Jan 28.
Polymeric tissue adhesives provide versatile materials for wound management and are widely used in a variety of medical settings ranging from minor to life-threatening tissue injuries. Compared to the traditional methods of wound closure (i.e., suturing and stapling), they are relatively easy to use, enable rapid application, and introduce minimal tissue damage. Furthermore, they can act as hemostats to control bleeding and provide a tissue-healing environment at the wound site. Despite their numerous current applications, tissue adhesives still face several limitations and unresolved challenges (e.g., weak adhesion strength and poor mechanical properties) that limit their use, leaving ample room for future improvements. Successful development of next-generation adhesives will likely require a holistic understanding of the chemical and physical properties of the tissue-adhesive interface, fundamental mechanisms of tissue adhesion, and requirements for specific clinical applications. In this review, we discuss a set of rational guidelines for design of adhesives, recent progress in the field along with examples of commercially available adhesives and those under development, tissue-specific considerations, and finally potential functions for future adhesives. Advances in tissue adhesives will open new avenues for wound care and potentially provide potent therapeutics for various medical applications.
聚合物组织粘合剂为伤口处理提供了多功能材料，广泛应用于从轻微到危及生命的各种组织损伤的医疗场景中。与传统的伤口闭合方法（即缝合和钉合）相比，它们使用相对简便，能够快速应用，并且对组织造成的损伤最小。此外，它们可以起到止血剂的作用来控制出血，并在伤口部位提供一个组织愈合的环境。尽管目前它们有众多应用，但组织粘合剂仍然面临一些限制和未解决的挑战（例如，粘附强度弱和机械性能差），这些限制了它们的使用，为未来的改进留下了很大空间。下一代粘合剂的成功开发可能需要全面了解组织 - 粘合剂界面的化学和物理性质、组织粘附的基本机制以及特定临床应用的要求。在这篇综述中，我们讨论了一套粘合剂设计的合理指导方针、该领域的最新进展以及市售粘合剂和正在开发的粘合剂的示例、组织特异性考虑因素，最后是未来粘合剂的潜在功能。组织粘合剂的进展将为伤口护理开辟新途径，并可能为各种医疗应用提供有效的治疗方法。
