CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao 266101, China.
CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao 266101, China.
Mater Sci Eng C Mater Biol Appl. 2020 Jun;111:110796. doi: 10.1016/j.msec.2020.110796. Epub 2020 Mar 5.
Tissue adhesives have emerged as an effective method for wound closure and hemostasis in recent decades, due to their ability to bond tissues together, preventing separation from one tissue to another. However, existing tissue adhesives still have several limitations. Tremendous efforts have been invested into developing new tissue adhesives by improving upon existing adhesives through different strategies. Therefore, highlighting and analyzing these design strategies are essential for developing the next generation of advanced adhesives. To this end, we reviewed the available strategies for modifying traditional adhesives (including cyanoacrylate glues, fibrin sealants and BioGlue), as well as design of emerging adhesives (including gelatin sealants, methacrylated sealants and bioinspired adhesives), focusing on their structures, adhesive mechanisms, advantages, limitations, and current applications. The bioinspired adhesives have numerous advantages over traditional adhesives, which will be a wise direction for achieving tissue adhesives with superior properties.
在最近几十年，由于能够将组织粘合在一起，防止组织彼此分离，组织粘合剂已成为一种有效的伤口闭合和止血方法。然而，现有的组织粘合剂仍然存在一些局限性。人们投入了巨大的努力通过不同的策略改进现有的粘合剂来开发新的组织粘合剂。因此，突出和分析这些设计策略对于开发下一代先进的粘合剂至关重要。为此，我们回顾了修饰传统粘合剂（包括氰基丙烯酸酯胶、纤维蛋白密封剂和 BioGlue）的现有策略，以及新兴粘合剂（包括明胶密封剂、甲基丙烯酰化密封剂和仿生粘合剂）的设计，重点关注它们的结构、粘合机制、优点、局限性和当前应用。仿生粘合剂具有许多优于传统粘合剂的优点，这将是实现具有优异性能的组织粘合剂的明智方向。
