Interdisciplinary Biological Sciences, Northwestern University, Evanston, USA.
Nanoscale Horiz. 2019 Mar 1;4(2):258-272. doi: 10.1039/c8nh00300a. Epub 2018 Nov 20.
Self-assembled soft nanocarriers that are capable of simultaneous encapsulation of both lipophilic and water soluble payloads have significantly enhanced controlled delivery applications in biomedicine. These nanoarchitectures, such as liposomes, polymersomes and cubosomes, are primarily composed of either amphiphilic polymers or lipids, with the polymeric variants generally possessing greater stability and control over biodistribution and bioresponsive release. Polymersomes have long demonstrated such advantages over their lipid analogs, liposomes, but only recently have bicontinuous nanospheres emerged as a polymeric cubic phase alternative to lipid cubosomes. In this review, we summarize the current state of the field for bicontinuous nanosphere formulation and characterization and suggest future directions for this nascent delivery platform as it is adopted for biomedical applications.
自组装的软纳载体能够同时包封亲脂性和水溶性有效载荷，在生物医学中显著增强了控制释放的应用。这些纳米结构，如脂质体、聚合物囊泡和立方纳米囊泡，主要由两亲性聚合物或脂质组成，其中聚合物变体通常具有更高的稳定性，并能更好地控制生物分布和生物响应性释放。聚合物囊泡在许多方面都优于其脂质类似物——脂质体，但直到最近，双连续纳米球才作为一种替代脂质立方纳米囊泡的聚合物立方相出现。在这篇综述中，我们总结了双连续纳米球制剂和表征的现状，并为这个新兴的给药平台在被用于生物医学应用时提出了未来的发展方向。
