Süβ Patrick, Lana Addison J, Schlachetzki Johannes C M
Department of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany.
Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Neural Regen Res. 2021 Sep;16(9):1711-1714. doi: 10.4103/1673-5374.306060.
The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question. Sustained activation of the peripheral innate and adaptive immune systems occurs in the context of a broad array of disorders ranging from chronic infectious diseases to autoimmune and metabolic diseases. In addition, progressive systemic inflammation is increasingly recognized during aging. Peripheral immune cells could potentially modulate the cellular brain environment via the secretion of soluble molecules. There is an ongoing debate whether peripheral immune cells have the potential to migrate into the brain under certain permissive circumstances. In this perspective, we discuss the possible contribution of chronic peripheral inflammation to the pathogenesis of age-related neurodegenerative diseases with a focus on microglia, the resident immune cells of the brain parenchyma.
慢性外周炎症对神经退行性疾病发病机制的作用是一个突出问题。外周固有免疫系统和适应性免疫系统的持续激活发生在从慢性传染病到自身免疫性疾病和代谢性疾病等一系列广泛疾病的背景下。此外，在衰老过程中，进行性全身炎症越来越受到认可。外周免疫细胞可能通过分泌可溶性分子来调节脑内细胞环境。外周免疫细胞在某些允许的情况下是否有潜力迁移到大脑中，目前仍存在争议。从这个角度出发，我们将讨论慢性外周炎症对与年龄相关的神经退行性疾病发病机制的可能作用，重点关注小胶质细胞，即脑实质中的常驻免疫细胞。
