Department of Neurology, Wroclaw Medical University, Wroclaw, Poland.
Department of General Radiology, Interventional Radiology and Neuroradiology, Wroclaw Medical University, Wroclaw, Poland.
Sci Rep. 2021 Jan 28;11(1):2480. doi: 10.1038/s41598-021-82281-6.
Thyroid dysfunction is very often accompanied by cognitive and affective disorders. The frequency of these disorders in patients with compensated Hashimoto's thyroiditis (HT) is unknown. The aim of the present study was to evaluate brain dysfunction in euthyroid HT patients by means of event-related potentials (ERP) and magnetic resonance spectroscopy (MRS) and to correlate it with cognitive function. 68 patients with HT (59 female, 9 male) and 45 healthy controls were included in the study. All the patients underwent ERP including an analysis of N200 and P300 response parameters. MRS voxels were located in the posterior cingulate gyrus (PCG) and the left parietal white matter (PWM). The NAA/Cr, mI/Cr, and Cho/Cr ratios were analysed. The ERP parameters, MRS metabolite ratios and hormonal concentrations (TSH, fT3, fT4) as well as TGAb and TPOAb titer were also correlated. There was a significant prolongation of the latencies of N200 and P300 potentials and a significant decrease of P300 amplitude in HT patients than in the control group. There was a significant positive correlation between the mI/Cr ratio in the PCG area and P300 latencies. NAA/Cr ratio in the PCG region showed significant negative correlations with all N200 latencies. The results may suggest brain dysfunction in neurologically asymptomatic HT patients. ERPs undergo significant changes in patients with HT and may, in combination with MRS, constitute an important element in the recognition and monitoring of cognitive functions in this group of patients.
甲状腺功能障碍常伴有认知和情感障碍。代偿性桥本甲状腺炎（HT）患者这些障碍的频率尚不清楚。本研究旨在通过事件相关电位（ERP）和磁共振波谱（MRS）评估甲状腺功能正常的 HT 患者的脑功能障碍，并将其与认知功能相关联。
研究纳入了 68 例 HT 患者（59 名女性，9 名男性）和 45 名健康对照者。所有患者均进行了 ERP 检查，包括 N200 和 P300 反应参数分析。MRS 体素位于后扣带回（PCG）和左侧顶叶白质（PWM）。分析 NAA/Cr、mI/Cr 和 Cho/Cr 比值。还分析了 ERP 参数、MRS 代谢物比值以及激素浓度（TSH、fT3、fT4）以及 TGAb 和 TPOAb 滴度。
与对照组相比，HT 患者的 N200 和 P300 潜伏期明显延长，P300 振幅明显降低。PCG 区 mI/Cr 比值与 P300 潜伏期呈显著正相关。PCG 区 NAA/Cr 比值与所有 N200 潜伏期呈显著负相关。
结果提示神经无症状 HT 患者存在脑功能障碍。HT 患者的 ERP 发生明显变化，与 MRS 相结合，可能成为识别和监测该组患者认知功能的重要因素。
