Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, Japan.
Tajimi Iwase Eye Clinic, Tajimi, Gifu, Japan.
Transl Vis Sci Technol. 2021 Jan 7;10(1):13. doi: 10.1167/tvst.10.1.13. eCollection 2021 Jan.
To investigate the ocular and systemic factors related to glaucoma and to be adjusted for interindividual comparison of ocular blood flow measurement results by laser speckle flowgraphy (LSFG) obtained from the optic nerve head (ONH) in normal Japanese individuals.
A multicenter, prospective cross-sectional study was conducted. The ONH tissue-area and vessel-area mean blur rate (MT and MV) were evaluated using LSFG and ONH structural parameters using planimetric methods. Multivariate linear mixed-effects modeled regression analysis was used to identify the contributing factors to the MT and MV. The explanatory variables were age; gender; smoking history; body mass index; mean arterial pressure (MAP); heart rate; intraocular pressure; axial length (AL); disc, rim, cup, and β-peripapillary atrophy (β-PPA) areas; and central retinal artery and vein equivalents.
In total, 195 eyes of 126 healthy individuals with an average age of 48.1 years were included. Multivariate analysis showed that MAP and disc area had a negative ( < 0.001) correlation, whereas β-PPA area had a positive correlation with MT ( = 0.010). Age and AL had a negative correlation ( = 0.001 and = 0.011, respectively), whereas cup area had a positive correlation ( = 0.012) with MV.
Interindividual comparison of MT or MV must be adjusted for both systemic factors (blood pressure or age) and local ocular factors (AL and disc, cup, or β-PPA area).
Our results provided reference data on the LSFG measurement and are important in comparing ocular blood flow between individuals using LSFG.
探讨与青光眼相关的眼内和全身因素，并对来自正常日本个体视神经头（ONH）的激光散斑血流图（LSFG）测量的眼血流结果进行个体间比较进行调整。
进行了一项多中心、前瞻性的横断面研究。使用 LSFG 评估 ONH 组织面积和血管面积平均模糊率（MT 和 MV），并使用平面测量法评估 ONH 结构参数。使用多元线性混合效应模型回归分析来确定 MT 和 MV 的影响因素。解释变量包括年龄；性别；吸烟史；体重指数；平均动脉压（MAP）；心率；眼压；眼轴（AL）；盘、环、杯和β-视盘旁萎缩（β-PPA）面积；以及视网膜中央动脉和静脉当量。
共纳入 126 名健康个体的 195 只眼，平均年龄为 48.1 岁。多变量分析显示，MAP 和盘面积呈负相关（<0.001），而β-PPA 面积与 MT 呈正相关（=0.010）。年龄和 AL 呈负相关（分别为=0.001 和=0.011），而杯面积与 MV 呈正相关（=0.012）。
MT 或 MV 的个体间比较必须同时调整全身因素（血压或年龄）和局部眼内因素（AL 和盘、杯或β-PPA 面积）。
杨阳
