Wei Zheng, Zou Huihui, Liu Gongyuan, Song Chuanhui, Tang Chuanchao, Chen Sheng, Zhang Guorong, Ran Jianchuan, Wang Yufeng, Yin Xiteng, Cai Yu, Han Wei
Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, China.
Pediatric Dentistry, Nanjing Stomatology Hospital, Medical School of Nanjing University, No 30 Zhongyang Road, Nanjing, 210008, China.
Bioact Mater. 2021 Jan 13;6(7):2144-2157. doi: 10.1016/j.bioactmat.2020.12.016. eCollection 2021 Jul.
Here, evodiamine (EVO) and the photosensitizer indocyanine green (ICG) were integrated into a liposomal nanoplatform for noninvasive diagnostic imaging and combinatorial therapy against oral squamous cell carcinoma (OSCC). EVO, as an active component extracted from traditional Chinese medicine, not only functioned as an antitumor chemotherapeutic agent but was also capable of Ga-chelation, thus working as a contrast agent for positron emission tomography/computed tomography (PET/CT) imaging. Moreover, EVO could exhibit peroxidase-like catalytic activity, converting endogenous tumor HO into cytotoxic reactive oxygen species (ROS), enabling Chemo catalytic therapy beyond the well-known chemotherapy effect of EVO. As proven by and experiments, guided by optical imaging and PET/CT imaging, we show that the theragnostic liposomes have a significant inhibiting effect on in situ tongue tumor through photodynamic therapy combined with chemodynamic chemotherapy.
在此，将吴茱萸碱（EVO）和光敏剂吲哚菁绿（ICG）整合到脂质体纳米平台中，用于口腔鳞状细胞癌（OSCC）的无创诊断成像和联合治疗。EVO作为从中药中提取的活性成分，不仅作为抗肿瘤化疗药物发挥作用，还能够螯合镓，从而作为正电子发射断层扫描/计算机断层扫描（PET/CT）成像的造影剂。此外，EVO可表现出类过氧化物酶催化活性，将内源性肿瘤过氧化氢转化为细胞毒性活性氧（ROS），实现超越EVO众所周知的化疗效果的化学催化治疗。正如 实验和 实验所证明的，在光学成像和PET/CT成像的引导下，我们表明，该诊疗脂质体通过光动力疗法联合化学动力化疗对原位舌肿瘤具有显著的抑制作用。
