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基于活性氧调节的口腔疾病纳米疗法

Nanotherapies Based on ROS Regulation in Oral Diseases.

作者信息

Luo Xin, Zhang Yanli, Zeng Yuting, Yang Dehong, Zhou Zhiyan, Zheng Ziting, Xiao Ping, Ding Xian, Li Qianlin, Chen Jiaping, Deng Qianwen, Zhong Xincen, Qiu Sijie, Yan Wenjuan

机构信息

Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.

出版信息

Adv Sci (Weinh). 2025 Mar;12(9):e2409087. doi: 10.1002/advs.202409087. Epub 2025 Jan 30.

DOI:10.1002/advs.202409087
PMID:39887942
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11884622/
Abstract

Oral diseases rank among the most prevalent clinical conditions globally, typically involving detrimental factors such as infection, inflammation, and injury in their occurrence, development, and outcomes. The concentration of reactive oxygen species (ROS) within cells has been demonstrated as a pivotal player in modulating these intricate pathological processes, exerting significant roles in restoring oral functionality and maintaining tissue structural integrity. Due to their enzyme-like catalytic properties, unique composition, and intelligent design, ROS-based nanomaterials have garnered considerable attention in oral nanomedicine. Such nanomaterials have the capacity to influence the spatiotemporal dynamics of ROS within biological systems, guiding the evolution of intra-ROS to facilitate therapeutic interventions. This paper reviews the latest advancements in the design, functional customization, and oral medical applications of ROS-based nanomaterials. Through the analysis of the components and designs of various novel nanozymes and ROS-based nanoplatforms responsive to different stimuli dimensions, it elaborates on their impacts on the dynamic behavior of intra-ROS and their potential regulatory mechanisms within the body. Furthermore, it discusses the prospects and strategies of nanotherapies based on ROS scavenging and generation in oral diseases, offering alternative insights for the design and development of nanomaterials for treating ROS-related conditions.

摘要

口腔疾病是全球最普遍的临床病症之一，在其发生、发展和转归过程中通常涉及感染、炎症和损伤等有害因素。细胞内活性氧（ROS）的浓度已被证明是调节这些复杂病理过程的关键因素，在恢复口腔功能和维持组织结构完整性方面发挥着重要作用。基于ROS的纳米材料因其类酶催化特性、独特组成和智能设计，在口腔纳米医学中备受关注。这类纳米材料能够影响生物系统中ROS的时空动态，引导细胞内ROS的演变以促进治疗干预。本文综述了基于ROS的纳米材料在设计、功能定制及口腔医学应用方面的最新进展。通过分析各种新型纳米酶和基于ROS的纳米平台在不同刺激维度下的组成与设计，阐述了它们对细胞内ROS动态行为的影响及其在体内的潜在调控机制。此外，还讨论了基于ROS清除和生成的口腔疾病纳米治疗的前景与策略，为治疗ROS相关病症的纳米材料设计与开发提供了新的见解。

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