C-C Chemokine Receptor Seven (CCR7): Coming of Age In Vaccines.
作者信息
Bill Colin A, Soto Olga B, Vines Charlotte M
机构信息
Department of Biological Sciences, The University of Texas at El Paso, 500 W University Avenue, El Paso, TX 79968, USA.
出版信息
Vaccin Res. 2016 Apr;1(1):7-9.
Abstract
摘要
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本文引用的文献
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Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes.趋化因子受体CCR7在白细胞中由其配体CCL19和CCL21引发的常见且有偏向性的信号通路。
J Leukoc Biol. 2016 Jun;99(6):869-82. doi: 10.1189/jlb.2MR0815-380R. Epub 2016 Jan 4.
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Inner Workings: 1885, the first rabies vaccination in humans.内部运作：1885年，首次对人类进行狂犬病疫苗接种。
Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12273. doi: 10.1073/pnas.1414226111.
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History of vaccination.疫苗接种史。
Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12283-7. doi: 10.1073/pnas.1400472111. Epub 2014 Aug 18.
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CCR7/CCL19 controls expression of EDG-1 in T cells.CCR7/CCL19 控制 T 细胞中 EDG-1 的表达。
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Deficient CCR7 signaling promotes TH2 polarization and B-cell activation in vivo.CCR7 信号缺陷促进体内 TH2 极化和 B 细胞激活。
Eur J Immunol. 2012 Jan;42(1):48-57. doi: 10.1002/eji.201141753. Epub 2011 Nov 28.
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CCR7-deficient mice develop atypically persistent germinal centers in response to thymus-independent type 2 antigens.CCR7基因缺陷型小鼠在对非胸腺依赖性2型抗原产生应答时会形成非典型的持续性生发中心。
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