Zheng Yuanyuan, Hong Xiangqian, Wang Jiantao, Feng Longbao, Fan Taojian, Guo Rui, Zhang Han
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Guangdong Provincial Engineering and Technological Research Center for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, P. R. China.
Shenzhen Eye Institute, Shenzhen Eye Hospital Affiliated to Jinan University, School of Optometry, Shenzhen University, Shenzhen, 518040, P. R. China.
Adv Healthc Mater. 2021 Apr;10(7):e2001743. doi: 10.1002/adhm.202001743. Epub 2021 Jan 29.
Regenerative medicine has become one of the hottest research topics in medical science that provides a promising way for repairing tissue defects in the human body. Due to their excellent physicochemical properties, the application of 2D nanomaterials in regenerative medicine has gradually developed and has been attracting a wide range of research interests in recent years. In particular, graphene and its derivatives, black phosphorus, and transition metal dichalcogenides are applied in all the aspects of tissue engineering to replace or restore tissues. This review focuses on the latest advances in the application of 2D-nanomaterial-based hydrogels, nanosheets, or scaffolds that are engineered to repair skin, bone, and cartilage tissues. Reviews on other applications, including cardiac muscle regeneration, skeletal muscle repair, nerve regeneration, brain disease treatment, and spinal cord healing are also provided. The challenges and prospects of applications of 2D nanomaterials in regenerative medicine are discussed.
再生医学已成为医学领域最热门的研究课题之一，为修复人体组织缺陷提供了一条充满希望的途径。由于其优异的物理化学性质，二维纳米材料在再生医学中的应用逐渐发展起来，近年来吸引了广泛的研究兴趣。特别是，石墨烯及其衍生物、黑磷和过渡金属二硫化物被应用于组织工程的各个方面，以替代或修复组织。本综述重点关注基于二维纳米材料的水凝胶、纳米片或支架在修复皮肤、骨骼和软骨组织方面的最新应用进展。还提供了关于其他应用的综述，包括心肌再生、骨骼肌修复、神经再生、脑部疾病治疗和脊髓愈合。讨论了二维纳米材料在再生医学应用中的挑战和前景。
