Pneumology Department, Hospital Universitario La Princesa. Instituto De Investigación Sanitaria La Princesa, Madrid, Spain.
Pneumology Department, Hospital Universitario La Fe, Valencia, Spain.
Expert Rev Respir Med. 2021 Apr;15(4):477-491. doi: 10.1080/17476348.2021.1882853. Epub 2021 Mar 1.
: Interest in bronchiectasis is increasing due to its rising prevalence, associated with aging populations and the extended use of high-resolution chest tomography (HRCT), and the resulting high morbidity, mortality, and demand for resources.: This article provides an extensive review of bronchiectasis as a complex and heterogeneous disease, as well as examining the difficulty of establishing useful clinical phenotypes. In keeping with the aims of 'precision medicine', we address the disease of bronchiectasis from three specific perspectives: severity, activity, and impact. We used PubMed to search the literature for articles including the following keywords: personalized medicine, bronchiectasis, biomarkers, phenotypes, precision medicine, treatable traits. We reviewed the most relevant articles published over the last 5 years.: This article reflects on the usefulness of these three dimensions in 'control panels' and clinical fingerprinting, as well as approaches to personalized medicine and the treatable features of bronchiectasis non-cystic fibrosis.
由于支气管扩张症的发病率不断上升，与人口老龄化和高分辨率胸部 CT（HRCT）的广泛应用有关，以及由此导致的高发病率、死亡率和对资源的需求增加，人们对其兴趣日益增加。本文对支气管扩张症这一复杂和异质性疾病进行了广泛的综述，并探讨了建立有用的临床表型的困难。为了与“精准医学”的目标保持一致，我们从严重程度、活动度和影响三个特定角度来探讨支气管扩张症的问题。我们使用 PubMed 搜索了包括以下关键词的文献：个体化医学、支气管扩张症、生物标志物、表型、精准医学、可治疗特征。我们回顾了过去 5 年发表的最相关的文章。本文思考了这三个维度在“控制面板”和临床特征分析中的作用，以及个体化医学和非囊性纤维化支气管扩张症的可治疗特征的方法。
