支气管扩张症患者患肺癌的风险是否增加？一项系统评价。
Do Patients with Bronchiectasis Have an Increased Risk of Developing Lung Cancer? A Systematic Review.
作者信息
Castaldo Nadia, Fantin Alberto, Manera Massimiliano, Patruno Vincenzo, Sartori Giulia, Crisafulli Ernesto
机构信息
Department of Pulmonology, University Hospital of Udine (ASUFC), 33100 Udine, Italy.
Respiratory Medicine Unit, Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, Italy.
出版信息
Life (Basel). 2023 Feb 7;13(2):459. doi: 10.3390/life13020459.
BACKGROUND
Initial evidence supports the hypothesis that patients with non-cystic fibrosis bronchiectasis (NCFB) have a higher risk of lung cancer. We systematically reviewed the available literature to define the characteristics of lung malignancies in patients with bronchiectasis and the characteristics of patients who develop bronchiectasis-associated lung cancer.
METHOD
This study was performed based on the PRISMA guidelines. The review protocol was registered in PROSPERO.
RESULTS
The frequency rates of lung cancer in patients with NCFB ranged from 0.93% to 8.0%. The incidence rate was 3.96. Cancer more frequently occurred in the elderly and males. Three studies found an overall higher risk of developing lung cancer in the NCFB population compared to the non-bronchiectasis one, and adenocarcinoma was the most frequently reported histological type. The effect of the co-existence of NCFB and COPD was unclear.
CONCLUSIONS
NCFB is associated with a higher risk of developing lung cancer than individuals without NCFB. This risk is higher for males, the elderly, and smokers, whereas concomitant COPD's effect is unclear.
背景
初步证据支持非囊性纤维化支气管扩张症（NCFB）患者患肺癌风险更高这一假说。我们系统回顾了现有文献，以明确支气管扩张症患者肺部恶性肿瘤的特征以及发生支气管扩张症相关肺癌患者的特征。
方法
本研究依据PRISMA指南开展。综述方案已在PROSPERO注册。
结果
NCFB患者的肺癌发生率在0.93%至8.0%之间。发病率为3.96。癌症在老年人和男性中更为常见。三项研究发现，与非支气管扩张症人群相比，NCFB人群患肺癌的总体风险更高，腺癌是最常报告的组织学类型。NCFB与慢性阻塞性肺疾病（COPD）并存的影响尚不清楚。
结论
与无NCFB的个体相比，NCFB与患肺癌的较高风险相关。男性、老年人和吸烟者的这种风险更高，而COPD并存的影响尚不清楚。
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