Fernández-Barahona Irene, Gutiérrez Lucía, Veintemillas-Verdaguer Sabino, Pellico Juan, Morales María Del Puerto, Catala Mauro, Del Pozo Miguel A, Ruiz-Cabello Jesús, Herranz Fernando
Instituto de Química Médica, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.
Universidad Complutense de Madrid and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), 28029 Madrid, Spain.
ACS Omega. 2019 Feb 6;4(2):2719-2727. doi: 10.1021/acsomega.8b03004. eCollection 2019 Feb 28.
Synthesizing iron oxide nanoparticles for positive contrast in magnetic resonance imaging is the most promising approach to bring this nanomaterial back to the clinical field. The success of this approach depends on several aspects: the longitudinal relaxivity values, the complexity of the synthetic protocol, and the reproducibility of the synthesis. Here, we show our latest results on this goal. We have studied the effect of Cu doping on the physicochemical, magnetic, and relaxometric properties of iron oxide nanoparticles designed to provide positive contrast in magnetic resonance imaging. We have used a one-step, 10 min synthesis to produce nanoparticles with excellent colloidal stability. We have synthesized three different Cu-doped iron oxide nanoparticles showing modest to very large longitudinal relaxivity values. Finally, we have demonstrated the in vivo use of these kinds of nanoparticles both in angiography and targeted molecular imaging.
合成用于磁共振成像正性对比的氧化铁纳米颗粒是使这种纳米材料重返临床领域最具前景的方法。该方法的成功取决于几个方面：纵向弛豫率值、合成方案的复杂性以及合成的可重复性。在此，我们展示了关于这一目标的最新成果。我们研究了铜掺杂对旨在提供磁共振成像正性对比的氧化铁纳米颗粒的物理化学、磁性和弛豫特性的影响。我们采用一步法、10分钟合成来制备具有优异胶体稳定性的纳米颗粒。我们合成了三种不同的铜掺杂氧化铁纳米颗粒，其纵向弛豫率值从中等至非常大。最后，我们证明了这类纳米颗粒在血管造影和靶向分子成像中的体内应用。
