Brancolini Claudio, Di Giorgio Eros, Formisano Luigi, Gagliano Teresa
Department of Medicine, Università degli Studi di Udine, p.le Kolbe 4, 33100 Udine, Italy.
Department of Neuroscience, School of Medicine, "Federico II" University of Naples, Via Pansini, 5, 80131 Naples, Italy.
Life (Basel). 2021 Jan 27;11(2):90. doi: 10.3390/life11020090.
Understanding how an epigenetic regulator drives different cellular responses can be a tricky task. Very often, their activities are modulated by large multiprotein complexes, the composition of which is context- and time-dependent. As a consequence, experiments aimed to unveil the functions of an epigenetic regulator can provide different outcomes and conclusions, depending on the circumstances. HDAC9 (histone deacetylase), an epigenetic regulator that influences different differentiating and adaptive responses, makes no exception. Since its discovery, different phenotypes and/or dysfunctions have been observed after the artificial manipulation of its expression. The cells and the microenvironment use multiple strategies to control and monitor HDAC9 activities. To date, some of the genes under HDAC9 control have been identified. However, the exact mechanisms through which HDAC9 can achieve all the different tasks so far described, remain mysterious. Whether it can assemble into different multiprotein complexes and how the cells modulate these complexes is not clearly defined. In summary, despite several cellular responses are known to be affected by HDAC9, many aspects of its network of interactions still remain to be defined.
理解一种表观遗传调节因子如何驱动不同的细胞反应可能是一项棘手的任务。通常，它们的活性由大型多蛋白复合物调节，而这些复合物的组成取决于环境和时间。因此，旨在揭示表观遗传调节因子功能的实验可能会根据情况提供不同的结果和结论。HDAC9（组蛋白去乙酰化酶）作为一种影响不同分化和适应性反应的表观遗传调节因子，也不例外。自其被发现以来，在人工操纵其表达后观察到了不同的表型和/或功能障碍。细胞和微环境使用多种策略来控制和监测HDAC9的活性。到目前为止，已经确定了一些受HDAC9控制的基因。然而，HDAC9实现迄今为止所描述的所有不同任务的确切机制仍然是个谜。它是否能组装成不同的多蛋白复合物以及细胞如何调节这些复合物尚不清楚。总之，尽管已知几种细胞反应受HDAC9影响，但其相互作用网络的许多方面仍有待确定。
