Cuttini Emma, Goi Camilla, Pellarin Ester, Vida Riccardo, Brancolini Claudio
Scuola Superiore Universitaria di Toppo Wassermann, Università degli Studi di Udine, Udine, Italy.
Laboratory of Epigenomics, Department of Medicine, Università degli Studi di Udine, Udine, Italy.
Front Mol Biosci. 2023 Jan 24;10:1116660. doi: 10.3389/fmolb.2023.1116660. eCollection 2023.
Controlling access to genomic information and maintaining its stability are key aspects of cell life. Histone acetylation is a reversible epigenetic modification that allows access to DNA and the assembly of protein complexes that regulate mainly transcription but also other activities. Enzymes known as histone deacetylases (HDACs) are involved in the removal of the acetyl-group or in some cases of small hydrophobic moieties from histones but also from the non-histone substrate. The main achievement of HDACs on histones is to repress transcription and promote the formation of more compact chromatin. There are 18 different HDACs encoded in the human genome. Here we will discuss HDAC4, a member of the class IIa family, and its possible contribution to cancer development.
控制对基因组信息的访问并维持其稳定性是细胞生命的关键方面。组蛋白乙酰化是一种可逆的表观遗传修饰，它允许对DNA进行访问，并组装主要调节转录但也调节其他活动的蛋白质复合物。被称为组蛋白去乙酰化酶（HDACs）的酶参与从组蛋白以及非组蛋白底物中去除乙酰基或在某些情况下去除小的疏水部分。HDACs对组蛋白的主要作用是抑制转录并促进更紧密染色质的形成。人类基因组中编码了18种不同的HDACs。在这里，我们将讨论IIa类家族的成员HDAC4及其对癌症发展的可能贡献。
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