Jessop Ignacio A, Pérez Yasmín P, Jachura Andrea, Nuñez Hipólito, Saldías Cesar, Isaacs Mauricio, Tundidor-Camba Alain, Terraza Claudio A, Araya-Durán Ingrid, Camarada María B, Cárcamo-Vega José J
Organic and Polymeric Materials Research Laboratory, Facultad de Ciencias, Universidad de Tarapacá. P.O. Box 7-D, Arica 1000007, Chile.
Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile.
Polymers (Basel). 2021 Jan 27;13(3):401. doi: 10.3390/polym13030401.
In the search for new materials to fight against antibiotic-resistant bacteria, a hybrid composite from metallic copper nanoparticles (CuNPs) and a novel cationic π-conjugated polyelectrolyte (CPE) were designed, synthesized, and characterized. The CuNPs were prepared by chemical reduction in the presence of CPE, which acts as a stabilizing agent. Spectroscopic analysis and electron microscopy showed the distinctive band of the metallic CuNP surface plasmon and their random distribution on the CPE laminar surface, respectively. Theoretical calculations on CuNP/CPE deposits suggest that the interaction between both materials occurs through polyelectrolyte side chains, with a small contribution of its backbone electron density. The CuNP/CPE composite showed antibacterial activity against Gram-positive ( and ) and Gram-negative ( and ) bacteria, mainly attributed to the CuNPs' effect and, to a lesser extent, to the cationic CPE.
在寻找对抗抗生素耐药细菌的新材料的过程中，设计、合成并表征了一种由金属铜纳米颗粒（CuNPs）和新型阳离子π共轭聚电解质（CPE）组成的混合复合材料。CuNPs是在作为稳定剂的CPE存在下通过化学还原制备的。光谱分析和电子显微镜分别显示了金属CuNP表面等离子体的独特波段及其在CPE层状表面上的随机分布。对CuNP/CPE沉积物的理论计算表明，两种材料之间的相互作用是通过聚电解质侧链发生的，其主链电子密度贡献较小。CuNP/CPE复合材料对革兰氏阳性菌（和）和革兰氏阴性菌（和）具有抗菌活性，这主要归因于CuNPs的作用，在较小程度上也归因于阳离子CPE。
