Department of Internal Medicine, Medical University of Lublin, 20-081 Lublin, Poland.
Chair and Department of Humanities and Social Medicine, Medical University of Lublin, 20-093 Lublin, Poland.
Int J Environ Res Public Health. 2021 Jan 27;18(3):1115. doi: 10.3390/ijerph18031115.
In view of previous reports, it is important to determine the relationship between liver function and the level of fluoride in the serum. The aim of this study was to investigate serum concentrations of fluoride in 72 patients with alcoholic liver cirrhosis, living in the region of Lublin (Eastern Poland) divided based on the severity of disease according to the Child-Turcotte-Pugh criteria. Higher plasma fluoride concentrations were associated with changes in liver related parameters. In all groups of analyzed patients with different stages of alcoholic liver cirrhosis, elevated levels of plasma fluoride and increased activities of both alanine aminotransferase (ALT) and total bilirubin concentration were shown.
鉴于以往的报告，确定肝功能与血清氟水平之间的关系非常重要。本研究的目的是调查居住在卢布林地区（波兰东部）的 72 例酒精性肝硬化患者的血清氟浓度，根据 Child-Turcotte-Pugh 标准根据疾病的严重程度进行分组。较高的血浆氟浓度与肝相关参数的变化有关。在酒精性肝硬化不同阶段的所有分析患者组中，均显示出血浆氟水平升高和丙氨酸氨基转移酶（ALT）和总胆红素浓度升高。
