Pappalardo Federico, Malara Giulia, Montisci Andrea
Department of Anesthesia and Intensive Care, IRCCS ISMETT, UPMC Italy, 90127 Palermo, Italy.
Cardiothoracic Center, Department of Anesthesia and Intensive Care, Istituto Clinico Sant'Ambrogio, 20149 Milan, Italy.
Membranes (Basel). 2021 Jan 27;11(2):87. doi: 10.3390/membranes11020087.
Cardiogenic shock following acute myocardial infarction is associated with high mortality, substantially unchanged for the previous 20 years. Several approaches have been sought to achieve a therapeutic breakthrough, from myocardial revascularization strategies to the use of mechanical circulatory support. Many issues are, as yet, unresolved. Systemic inflammation seems to play a key role but is still lacking in effective therapies, and is potentially compounded by the death spiral of hypoperfusion and/or artificial devices. In this review, a multitarget approach to cardiogenic shock following acute myocardial infarction is proposed.
急性心肌梗死后的心源性休克与高死亡率相关，在过去20年中基本没有变化。人们一直在寻求多种方法来实现治疗突破，从心肌血运重建策略到使用机械循环支持。然而，许多问题仍未得到解决。全身炎症似乎起着关键作用，但仍缺乏有效的治疗方法，并且可能因灌注不足和/或人工装置的死亡螺旋而加剧。在这篇综述中，提出了一种针对急性心肌梗死后心源性休克的多靶点治疗方法。
