Bishop P B
Department of Pathology, Faculty of Medicine, Acute Care Hospital, University of British Columbia, Vancouver, Canada.
J Manipulative Physiol Ther. 1988 Feb;11(1):36-40.
Proteoglycans are high molecular weight glycoproteins found in connective tissue. They imbibe water into intervertebral disc and apophyseal joint articular cartilage, endowing the tissues with elasticity and compressibility. A decrease in total tissue content of proteoglycans appears to predispose intervertebral disc to degeneration. The earliest tissue changes associated with the onset of spondylosis occur at the molecular level and may include alterations in proteoglycan structure and content. A number of models have been suggested to describe the relationship between changes in proteoglycan composition and degenerative changes in cartilage and intervertebral disc.
蛋白聚糖是存在于结缔组织中的高分子量糖蛋白。它们将水吸入椎间盘和椎间关节的关节软骨，赋予这些组织弹性和可压缩性。蛋白聚糖的总组织含量降低似乎使椎间盘易于退变。与脊柱病发病相关的最早组织变化发生在分子水平，可能包括蛋白聚糖结构和含量的改变。已经提出了一些模型来描述蛋白聚糖组成变化与软骨和椎间盘退变变化之间的关系。
