DeGalan M R, Schwendner S W, Skinner R W, Longino M A, Gross M, Counsell R E
Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109-0626.
J Nucl Med. 1988 Apr;29(4):503-8.
Rabbits rendered atherosclerotic by mechanical aortic de-endothelialization and 6 wk of cholesterol feeding were administered estradiol-17 beta-cypionate, an anti-atherogenic agent in rabbits. These animals were compared to a similar, untreated group and control animals fed a regular non-atherogenic diet. Iodine-125 cholesteryl iopanoate ([125I]Cl), a nonhydrolyzable cholesteryl ester derivative, was administered intravenously at regular intervals throughout the study. Six days after the last dose of [125I]Cl, the animals were scanned with a gamma camera. After animals were killed, tissue distribution of the 125I radioactivity showed a significant decrease of [125I]CI accumulation in the aorta of estrogen-treated as compared to untreated, cholesterol-fed animals. However, the accumulation of [125I]CI in the aortas was insufficient to accurately define the presence of atheroma by gamma camera scintigraphy.
通过机械性主动脉去内皮化和6周胆固醇喂养使兔子形成动脉粥样硬化，然后给这些兔子注射17β-雌二醇环戊丙酸酯，一种对兔子有抗动脉粥样硬化作用的药物。将这些动物与相似的未治疗组以及喂食常规非致动脉粥样硬化饮食的对照动物进行比较。在整个研究过程中定期静脉注射不可水解的胆固醇酯衍生物碘-125胆甾醇碘番酸酯（[125I]Cl）。在最后一剂[125I]Cl注射6天后，用γ相机对动物进行扫描。动物处死之后，125I放射性的组织分布显示，与未接受雌激素治疗、喂食胆固醇的动物相比，雌激素治疗组动物主动脉中[125I]Cl的积累显著减少。然而，通过γ相机闪烁扫描法，[125I]Cl在主动脉中的积累不足以准确界定动脉粥样瘤的存在。
