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柴胡皂苷对氨暴露诱导肉鸡回肠损伤的保护作用。

Protective effect of dietary supplementation of Bupleurum falcatum L saikosaponins on ammonia exposure-induced ileum injury in broilers.

机构信息

Department of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.

Department of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.

出版信息

Poult Sci. 2021 Mar;100(3):100803. doi: 10.1016/j.psj.2020.10.057. Epub 2020 Nov 2.

DOI:10.1016/j.psj.2020.10.057
PMID:33516464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7936159/
Abstract

Ammonia (NH) at a high concentration has been recognized as a highly poisonous pollutant affecting both air and water quality. NH, as a stimulus, exerts negative impact on broiler growth and production, but the molecular mechanisms are not clear yet. This study was designed to evaluate the effects of dietary supplementation of Bupleurum falcatum L saikosaponins (SP) on the growth and ileum health status in broilers exposed to NH. Day-old Arbor Acers broilers (n = 480) were randomly allocated into 1 of 4 treatments. The main factors were dietary SP supplementation (0 or 80 mg/kg of diet) and NH challenge (with or without 70 ± 5 ppm NH). The data of growth, intestinal morphology, and mRNA expression related to ileal function were collected from broilers exposed to NH for 7 d. Results showed that NH remarkably suppressed growth performance and intestinal development as well as induced biological injuries in the ileum of broilers, resulting from oxidative stress, mucous barrier damage, and immune dysfunction as well as upregulated apoptosis. These negative effects of NH were alleviated by the SP supplement. In conclusion, dietary supplementation of SP may be helpful in alleviating the detrimental effects of NH on the ileum development in broilers.

摘要

高浓度的氨（NH）已被认为是一种对空气质量和水质都有负面影响的高毒性污染物。NH 作为一种刺激物，对肉鸡的生长和生产产生负面影响，但分子机制尚不清楚。本研究旨在评估柴胡皂苷（SP）对暴露于 NH 的肉鸡生长和回肠健康状况的影响。本研究将 480 只 1 日龄的 Arbor Acers 肉鸡随机分配到 4 个处理组之一。主要因素是日粮 SP 补充（0 或 80mg/kg 日粮）和 NH 挑战（有或没有 70±5ppm NH）。暴露于 NH 7d 的肉鸡采集生长、肠道形态和与回肠功能相关的 mRNA 表达数据。结果表明，NH 显著抑制了肉鸡的生长性能和肠道发育，并诱导了回肠的生物损伤，这是由于氧化应激、粘液屏障损伤和免疫功能障碍以及细胞凋亡增加所致。SP 的补充缓解了 NH 的这些负面影响。总之，日粮中添加 SP 可能有助于缓解 NH 对肉鸡回肠发育的不利影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/f0977118c81d/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/80ad139ebfee/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/cdfd89b4e167/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/ee2eddb48f45/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/e0c4dd07a854/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/42277dd0ef19/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/cc9f0dd80084/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/f40283034c84/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/f0977118c81d/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/80ad139ebfee/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/cdfd89b4e167/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/ee2eddb48f45/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/e0c4dd07a854/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/42277dd0ef19/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/cc9f0dd80084/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/f40283034c84/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/7936159/f0977118c81d/gr8.jpg

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