Department of Orthopaedics, Golden Jubilee National Hospital, Clydebank, UK.
Luzerner Kantonsspital, Luzern, Switzerland; Orthopaedic Clinic Lucerne, Hirslanden Clinic St. Anna, Lucerne.
J Arthroplasty. 2021 May;36(5):1700-1706. doi: 10.1016/j.arth.2020.12.032. Epub 2020 Dec 26.
Addition of vitamin E to polyethylene is theorized to reduce the potential for oxidative wear in acetabular components. This paper presents a multicenter prospective cohort study that reports on outcomes from use of a Vitamin E-infused highly cross-linked polyethylene acetabular cup.
Patients were recruited across nine medical institutions. Clinical outcome measures recorded were the Harris Hip Score, visual analogue score for pain and satisfaction. Evidence of implant loosening or osteolysis was collected radiologically. Cup survival and reasons for revision in relevant cases were also recorded. Data collection was undertaken preoperatively, at 6-12 weeks, 6 months, 1 year, 2 years, and 5 years. A total of 675 patients were recruited, with 450 cases available at final review. Data regarding cup survival was available to 8 years and 9 months postoperatively.
Improvements in both the Harris Hip Score and visual analogue score for pain and satisfaction were recorded at all time points, with these being maintained through the length of follow-up. In total, 89% of cups were implanted within the Lewinnek safe zone. A lucent line was identified in one case, with no evidence of acetabular osteolysis observed throughout the follow-up period. Cup survival was 98.9% at 8 years and 9 months. No revisions for aseptic loosening were observed.
The use of a vitamin E-infused polyethylene acetabular cup demonstrates reassuring patient-reported outcomes, radiological measures, and cup survival at medium to long-term follow-up.
理论上，在聚乙烯中添加维生素 E 可以减少髋臼部件发生氧化磨损的可能性。本文介绍了一项多中心前瞻性队列研究，该研究报告了使用维生素 E 注入的高交联聚乙烯髋臼杯的结果。
患者在九个医疗机构中招募。记录的临床结果测量包括 Harris 髋关节评分、疼痛视觉模拟评分和满意度。收集了影像学证据来评估植入物松动或骨溶解的情况。还记录了与翻修相关的髋臼杯存活率和翻修原因。数据采集在术前、6-12 周、6 个月、1 年、2 年和 5 年进行。共招募了 675 名患者，最终有 450 例可进行回顾性分析。术后 8 年 9 个月时获得了有关髋臼杯存活率的数据。
所有时间点的 Harris 髋关节评分、疼痛视觉模拟评分和满意度均有改善，并且在随访期间得到了维持。总的来说，89%的髋臼杯植入在 Lewinnek 安全区内。有 1 例出现透亮线，但在整个随访期间未观察到髋臼骨溶解。髋臼杯的 8 年 9 个月的存活率为 98.9%。未观察到无菌性松动的翻修。
在中长期随访中，使用维生素 E 注入的聚乙烯髋臼杯可提供令人放心的患者报告结果、影像学测量和髋臼杯存活率。
