Departments of Biological Sciences, Tennessee State UnIversity, Nashville, TN, 37209, United States.
Department of Chemistry, Tennessee State University, Nashville, TN, 37209, United States.
Environ Toxicol Pharmacol. 2021 Apr;83:103599. doi: 10.1016/j.etap.2021.103599. Epub 2021 Jan 28.
Triclosan (TCS) is widely used in personal hygiene products, such as mouthwash and toothpaste, and is found in human tissues. Interleukin (IL)-1 beta (IL-1β), IL-6, tumor necrosis factor alpha (TNFα), and interferon gamma (IFNγ) are pro-inflammatory cytokines and inappropriately elevated levels of each have been associated with pathologies including rheumatoid arthritis and certain cancers. Here we examine effects of TCS on the secretion of the pro-inflammatory cytokines from human immune cell preparations. TCS at concentrations between 0.05-5 μM consistently increased the secretion of IL-1β, IL-6, and TNFα within 24 h of exposure and the increases often maintained out to 6 days of exposure. TCS also induced increases in IFNγ secretion, however the increases were most consistent after 48 h of exposure rather than within 24 h. Additionally, a role for both p44/42 and p38 MAPK in TCS-stimulated increases in IL-1β was seen in cells from some donors.
三氯生（TCS）广泛用于个人卫生产品，如漱口剂和牙膏，并存在于人体组织中。白细胞介素（IL）-1β（IL-1β）、IL-6、肿瘤坏死因子α（TNFα）和干扰素γ（IFNγ）是促炎细胞因子，每种细胞因子水平的升高都与包括类风湿关节炎和某些癌症在内的病理有关。在这里，我们研究了 TCS 对人免疫细胞制剂中促炎细胞因子分泌的影响。TCS 在 0.05-5μM 的浓度范围内，在暴露后 24 小时内持续增加 IL-1β、IL-6 和 TNFα 的分泌，并且这种增加通常在暴露 6 天内保持。TCS 还诱导 IFNγ 分泌增加，但是这种增加在 48 小时后而不是在 24 小时内更为一致。此外，在一些供体的细胞中，TCS 刺激的 IL-1β 增加与 p44/42 和 p38 MAPK 均有关。
