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波兰人体发样中三氯生的存在——一项初步研究。

The Presence of Triclosan in Human Hair Samples in Poland-A Pilot Study.

机构信息

Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-957 Olsztyn, Poland.

Laboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Crete, Greece.

出版信息

Int J Environ Res Public Health. 2022 Mar 23;19(7):3796. doi: 10.3390/ijerph19073796.

Abstract

Triclosan (TCS) is an organic substance showing antibacterial action, which is commonly used in many branches of industry, including, among others, cosmetics, pharmaceuticals and the food industry. TCS may penetrate into living organisms and negatively affect the health of humans and animals. The majority of previous investigations on TCS biomonitoring in humans have been performed on urine, but currently, studies on hair samples are becoming increasingly important. The aim of this study was to evaluate TCS concentration levels in residents of Olsztyn, a city in northeastern Poland, using a liquid chromatography-mass spectrometry technique. The presence of TCS was observed in 96.7% of samples tested, with concentration levels from 37.9 pg/mg to 3386.5 pg/mg. The mean concentration level of TCS in the present study was 402.6 (±803.6) pg/mg, and the median value was 103.3 pg/mg. Although there were some differences in TCS concentration levels between males and females, humans of various ages and humans with colored and natural hair had no statistically significant differences in TCS concentration levels. The obtained results have clearly indicated that people living in northeastern Poland are exposed to TCS to a large degree, and hair analysis, despite some limitations, is a suitable method for TCS biomonitoring in humans.

摘要

三氯生(TCS)是一种具有抗菌作用的有机物质,广泛应用于许多行业,包括化妆品、制药和食品工业等。TCS 可能会渗透到生物体中,并对人类和动物的健康产生负面影响。先前对人类 TCS 生物监测的大多数研究都是在尿液中进行的,但目前,对头发样本的研究变得越来越重要。本研究旨在使用液相色谱-质谱技术评估波兰东北部城市奥尔什丁居民的 TCS 浓度水平。在测试的 96.7%的样本中观察到 TCS 的存在,浓度范围为 37.9 pg/mg 至 3386.5 pg/mg。本研究中 TCS 的平均浓度水平为 402.6(±803.6)pg/mg,中位数为 103.3 pg/mg。尽管男性和女性之间的 TCS 浓度水平存在一些差异,但不同年龄的人和有颜色和自然头发的人之间的 TCS 浓度水平没有统计学上的显著差异。研究结果表明,生活在波兰东北部的人们暴露在 TCS 中的程度很大,尽管头发分析存在一些局限性,但它是一种适合人类 TCS 生物监测的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd4/8998057/fd8a8020d1d3/ijerph-19-03796-g001.jpg

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