INMED, INSERM, Aix-Marseille Universiteé, France (C.P.-B., N.H., C.P., J.L.).
Aix-Marseille Universiteé, CNRS, ISM, France (C.P.-B., N.H., A.C., E.B.).
Stroke. 2021 Mar;52(3):1109-1114. doi: 10.1161/STROKEAHA.120.031873. Epub 2021 Feb 1.
The objective is to compare the effects of high-intensity interval training (HIIT) with long versus short intervals on endurance and motor performance. Their influence on neuroplasticity markers is assessed in the ipsilesional and contralesional cortex and hippocampus since their remodeling could improve functional recovery.
Rats performed work-matched HIIT4 (long intervals: 4 minutes) or HIIT1 (short intervals: 1 minute) on treadmill for 2 weeks following transient middle cerebral artery occlusion. Forelimb grip strength evaluated motor function while incremental exercise tests measured the endurance performance. Key neuroplasticity markers were assessed by Western blot.
Both regimens were effective in enhancing both the speed associated with the lactate threshold and maximal speed at D8 and D15. Neuroplasticity markers were upregulated in the contralesional hemisphere after training contrary to the ipsilesional side. Grip strength completely recovered but is faster with HIIT4.
HIIT with short and long intervals induced early aerobic fitness and grip strength improvements. Our findings revealed that neuroplasticity markers were upregulated in the contralesional cortex and hippocampus to promote functional recovery.
本研究旨在比较高强度间歇训练（HIIT）的长时程与短时程干预对耐力和运动表现的影响。由于神经重塑有助于改善功能恢复，本研究还评估了 HIIT 对同侧和对侧大脑皮质及海马区神经可塑性标志物的影响。
大鼠经短暂性大脑中动脉闭塞后，在跑步机上进行工作匹配的 HIIT4（长时程：4 分钟）或 HIIT1（短时程：1 分钟）训练，持续 2 周。改良 forelimb grip strength 测试评估运动功能，递增运动测试测量耐力表现。通过 Western blot 检测关键神经可塑性标志物。
两种方案均能有效提高乳酸阈相关速度和 D8、D15 时的最大速度。与同侧大脑半球相反，训练后对侧大脑半球的神经可塑性标志物上调。握力完全恢复，但 HIIT4 恢复更快。
短时间和长时间 HIIT 均能早期提高有氧适能和握力。本研究结果表明，神经可塑性标志物在对侧皮质和海马区上调，以促进功能恢复。
