INMED, INSERM, Aix-Marseille University, 13007 Marseille, France.
CNRS, ISM, Aix-Marseille University, 13007 Marseille, France.
Int J Mol Sci. 2021 Mar 16;22(6):3003. doi: 10.3390/ijms22063003.
Stroke-induced cognitive impairments affect the long-term quality of life. High-intensity interval training (HIIT) is now considered a promising strategy to enhance cognitive functions. This review is designed to examine the role of HIIT in promoting neuroplasticity processes and/or cognitive functions after stroke. The various methodological limitations related to the clinical relevance of studies on the exercise recommendations in individuals with stroke are first discussed. Then, the relevance of HIIT in improving neurotrophic factors expression, neurogenesis and synaptic plasticity is debated in both stroke and healthy individuals (humans and rodents). Moreover, HIIT may have a preventive role on stroke severity, as found in rodents. The potential role of HIIT in stroke rehabilitation is reinforced by findings showing its powerful neurogenic effect that might potentiate cognitive benefits induced by cognitive tasks. In addition, the clinical role of neuroplasticity observed in each hemisphere needs to be clarified by coupling more frequently to cellular/molecular measurements and behavioral testing.
卒中引起的认知障碍会影响患者的长期生活质量。高强度间歇训练（HIIT）现被认为是一种提高认知功能的有前途的策略。本综述旨在探讨 HIIT 在促进卒中后神经可塑性过程和/或认知功能中的作用。首先讨论了与卒中患者运动建议的临床相关性相关的各种方法学限制。然后，在卒中患者和健康个体（人类和啮齿动物）中，探讨了 HIIT 对神经营养因子表达、神经发生和突触可塑性的改善作用。此外，在啮齿动物中发现 HIIT 可预防卒中严重程度，进一步证实了 HIIT 在卒中康复中的作用。HIIT 具有强大的神经发生作用，可能增强认知任务引起的认知益处，这一发现也加强了 HIIT 在卒中康复中的作用。此外，需要通过更频繁地结合细胞/分子测量和行为测试来阐明每个半球中观察到的神经可塑性的临床作用。
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