Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.
Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.
Intern Med. 2021 Jul 15;60(14):2261-2268. doi: 10.2169/internalmedicine.5906-20. Epub 2021 Feb 1.
Dendriform pulmonary ossification (DPO) is a rare condition characterized by metaplastic bone formation in the lung parenchyma. It has been reported to be often associated with primary lung diseases, such as usual interstitial pneumonia (UIP) or chronic aspiration of gastric acid; however, its clinical features and pathophysiology remain unclear, especially in idiopathic cases. We herein report five DPO cases, including three with an idiopathic origin. In all cases of idiopathic DPO, the pathological and radiological examinations showed localized pulmonary lesions suggesting inflammation or hemorrhaging.
树突状肺骨化（DPO）是一种罕见的疾病，其特征是肺实质中的骨形成。它常与原发性肺部疾病有关，如普通间质性肺炎（UIP）或胃酸慢性吸入；然而，其临床特征和病理生理学仍不清楚，特别是在特发性病例中。本文报告了 5 例 DPO 病例，其中 3 例为特发性。在所有特发性 DPO 病例中，病理和影像学检查均显示局部肺部病变，提示炎症或出血。
