Baptista Pedro Manuel, Silva Nisa, Coelho João, José Diana, Almeida Daniel, Meireles Angelina
Ophthalmology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Instituto de Ciências Biomédicas Abel Salazar, Porto, Portugal.
Clin Ophthalmol. 2021 Jan 22;15:235-242. doi: 10.2147/OPTH.S294662. eCollection 2021.
To characterize a population of high myopes with myopic traction maculopathy (MTM), to assess their retinal function, and to correlate it with anatomic status.
This was an observational cross-sectional study including 50 eyes from 27 patients. Demographic and clinical data were analyzed. Macular structure was assessed with spectral domain optical coherence tomography (SD-OCT, Heidelberg) and macular function was studied with Microperimeter MP-3, NIDEK.
The average for central foveal thickness (CFT) and choroid thickness (CT) was 213±151 μm and 36±23 μm, respectively, in a total of 50 eyes from 27 patients. In the microperimetry analysis, the average sensitivity on the foveal-centered 12º polygon (CPS) was 14.37±9.1 dB. CT was negatively associated with the bivariate contour ellipse areas (BCEA) 1 (r=-0.314; p=0.034), 2 (r=-0.314; p=0.034), and 3 (r=-0.316; p=0.033). CPS had a strong positive correlation with best-corrected visual acuity (BCVA) (r=0.661; p=0.000). We found a trend to worse microperimetric results in eyes with schisis (n=19) (p>0.05) but eyes with atrophic areas (n=33) presented significant inferior CPS (p<0.001). The presence of staphyloma showed significant impact on macular sensitivities in eyes with areas of macular atrophy/fibrosis (p<0.05).
Macular microperimetry analysis can have a role as part of a multimodal anatomo-functional assessment for a more precise characterization of the high myopic patients with MTM, optimizing medical and surgical decisions.
对患有近视性牵拉性黄斑病变（MTM）的高度近视人群进行特征描述，评估其视网膜功能，并将其与解剖学状态相关联。
这是一项观察性横断面研究，纳入了27例患者的50只眼。对人口统计学和临床数据进行了分析。使用光谱域光学相干断层扫描（SD - OCT，海德堡）评估黄斑结构，使用尼德克Microperimeter MP - 3研究黄斑功能。
27例患者的50只眼中，中央凹厚度（CFT）和脉络膜厚度（CT）的平均值分别为213±151μm和36±23μm。在微视野分析中，以中央凹为中心的12°多边形（CPS）上的平均敏感度为14.37±9.1dB。CT与双变量轮廓椭圆面积（BCEA）1（r = - 0.314；p = 0.034）、2（r = - 0.314；p = 0.034）和3（r = - 0.316；p = 0.033）呈负相关。CPS与最佳矫正视力（BCVA）呈强正相关（r = 0.661；p = 0.000）。我们发现有劈裂的眼（n = 19）微视野结果有变差的趋势（p>0.05），但有萎缩区域的眼（n = 33）的CPS明显更低（p<0.001）。葡萄肿的存在对有黄斑萎缩/纤维化区域的眼的黄斑敏感度有显著影响（p<0.05）。
黄斑微视野分析可作为多模式解剖 - 功能评估的一部分，用于更精确地描述患有MTM的高度近视患者，优化医疗和手术决策。
