Awan Nusrat M, Meurling Imran J, O'Shea Donal
Department of Endocrinology and Diabetes, St. Vincent's University Hospital, Dublin, Ireland.
Department of Endocrinology, St. Columcille's Hospital, Dublin, Ireland.
Saudi J Med Med Sci. 2021 Jan-Apr;9(1):10-15. doi: 10.4103/sjmms.sjmms_561_20. Epub 2020 Dec 26.
The prevalence of obesity has more than doubled globally over the past few decades, with a 12-fold rise in extreme levels. Obesity, with its multiple complications, remains a major ongoing challenge for health-care professionals, as highlighted by the COVID-19 pandemic, where people with obesity had poorer outcomes. In this article, we review advances in our understanding of the pathophysiology underlying obesity, with a focus on the immune system and its interaction with both the adipose tissue organ and the gut microbiome. As our understanding of the causes and effects of obesity improves, opportunities should emerge, underpinned by rigorous laboratory and clinical research, to both better prevent and treat this global epidemic.
在过去几十年里，全球肥胖症患病率增加了一倍多，极端肥胖水平增长了12倍。肥胖及其多种并发症仍然是医疗保健专业人员面临的一项持续重大挑战，正如新冠疫情所凸显的那样，肥胖者的预后较差。在本文中，我们回顾了我们对肥胖潜在病理生理学理解的进展，重点关注免疫系统及其与脂肪组织器官和肠道微生物群的相互作用。随着我们对肥胖的成因和影响的理解不断加深，在严格的实验室和临床研究的支持下，应该会出现更好地预防和治疗这一全球流行病的机会。
