Department of Nutritional Sciences, Texas Tech University, Lubbock, TX, 79409, USA.
College of Human Sciences, Texas Tech University, Lubbock, TX, 79409, USA.
Mol Nutr Food Res. 2019 Oct;63(20):e1900149. doi: 10.1002/mnfr.201900149. Epub 2019 Aug 26.
Obesity is a complex disease and a major public health epidemic. Chronic, low-grade inflammation is a common underlying feature of obesity and associated metabolic diseases; adipose tissue is a major contributor to this systemic inflammation. Evidence shows that obesity-associated inflammation may originate from gut dysfunction, including changes in intestinal bacteria or microbiome profiles. Increasingly, food and plant bioactive compounds with antioxidant and anti-inflammatory properties are proposed to ameliorate obesity-associated inflammation. Among these, the health-promoting effects of anthocyanin-rich foods are of interest here. Specifically, this review summarizes the reported benefits of anthocyanins in obesity-associated inflammation and underlying molecular mechanisms, including the role of gut microbiome and cell signaling pathways regulated by anthocyanins both in vivo and in vitro.
肥胖是一种复杂的疾病，也是一种主要的公共健康流行病。慢性、低度炎症是肥胖和相关代谢性疾病的共同潜在特征；脂肪组织是这种全身炎症的主要贡献者。有证据表明，与肥胖相关的炎症可能起源于肠道功能障碍，包括肠道细菌或微生物组谱的变化。越来越多的具有抗氧化和抗炎特性的食物和植物生物活性化合物被提议来改善与肥胖相关的炎症。在这些化合物中，富含花青素的食物的促进健康作用引起了人们的关注。具体来说，本综述总结了花青素在肥胖相关炎症中的报道益处及其潜在的分子机制，包括花青素在体内和体外调节肠道微生物组和细胞信号通路的作用。
