Browning Craig M, Deal Joshua, Mayes Sam, Arshad Arslan, Rich Thomas C, Leavesley Silas J
Chemical and Biomolecular Engineering, University of South Alabama, AL 36688, USA.
Systems Engineering, University of South Alabama, AL 36688, USA.
Biomed Opt Express. 2020 Dec 10;12(1):247-271. doi: 10.1364/BOE.411640. eCollection 2021 Jan 1.
Colorectal cancer is the 3 leading cancer for incidence and mortality rates. Positive treatment outcomes have been associated with early detection; however, early stage lesions have limited contrast to surrounding mucosa. A potential technology to enhance early stagise detection is hyperspectral imaging (HSI). While HSI technologies have been previously utilized to detect colorectal cancer or post-operation, they have been difficult to employ in real-time endoscopy scenarios. Here, we describe an LED-based multifurcated light guide and spectral light source that can provide illumination for spectral imaging at frame rates necessary for video-rate endoscopy. We also present an updated light source optical ray-tracing model that resulted in further optimization and provided a ∼10X light transmission increase compared to the initial prototype. Future work will iterate simulation and benchtop testing of the hyperspectral endoscopic system to achieve the goal of video-rate spectral endoscopy.
结直肠癌是发病率和死亡率排名第三的癌症。积极的治疗结果与早期检测相关；然而，早期病变与周围黏膜的对比度有限。一种增强早期检测的潜在技术是高光谱成像（HSI）。虽然HSI技术此前已被用于检测结直肠癌或术后情况，但它们很难应用于实时内镜检查场景。在这里，我们描述了一种基于发光二极管的多分支光导和光谱光源，它可以为视频速率内镜所需帧率的光谱成像提供照明。我们还提出了一种更新的光源光线追踪模型，该模型实现了进一步优化，与初始原型相比，光传输增加了约10倍。未来的工作将对高光谱内镜系统进行迭代模拟和台式测试，以实现视频速率光谱内镜的目标。
