Cuschieri Sarah, Grech Stephan
Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.
Mater Dei Hospital, Msida, Malta.
J Diabetes Metab Disord. 2020 Jun 13;19(2):775-781. doi: 10.1007/s40200-020-00563-8. eCollection 2020 Dec.
Discrepancies exist between international bodies for the diagnosis of impaired fasting glucose (IFG). The aim of this study was to establish the IFG characteristics and evaluate the best diagnostic IFG criteria in a high risk dysglycaemic population.
An IFG population ( = 451) was identified from a national representative cross-sectional survey using a fasting blood glucose (FBG) ranging from 5.60 to 6.99 mmol/L. These participants were invited for a follow-up oral glucose tolerance test (OGTT). Both FBG results (health survey & OGTT) were evaluated in relation to different diagnostic IFG criteria (>5.6 mmol/L vs. >6.1 mmol/L) while comparing to the final OGTT glycemic diagnosis.
Out of the total survey population ( = 1861), 24.34% was diagnosed with IFG. Approximately 50% of the IFG's ( = 227) attended for the OGTT. The majority of the IFG population were male with an overweight-obese status. If the FBG cut-off point of 6.1 mmol/L was followed, more than a quarter of the population attending the OGTT would have had a missed dysglycaemic status.
High-risk dysglycaemic and body mass populations may establish a more accurate dysglycaemia diagnosis and outcome when following an FBG cut-off point of >5.60 mmol/L for IFG.
国际机构在空腹血糖受损（IFG）的诊断标准上存在差异。本研究的目的是确定IFG的特征，并评估高危血糖异常人群中最佳的IFG诊断标准。
从一项全国代表性横断面调查中，通过空腹血糖（FBG）范围在5.60至6.99 mmol/L确定了IFG人群（n = 451）。邀请这些参与者进行后续的口服葡萄糖耐量试验（OGTT）。将FBG结果（健康调查和OGTT）与不同的IFG诊断标准（>5.6 mmol/L与>6.1 mmol/L）进行评估，并与最终的OGTT血糖诊断进行比较。
在总调查人群（n = 1861）中，24.34%被诊断为IFG。约50%的IFG患者（n = 227）参加了OGTT。大多数IFG人群为男性，处于超重或肥胖状态。如果遵循6.1 mmol/L的FBG切点，参加OGTT的人群中有超过四分之一的人血糖异常状态会被漏诊。
对于高危血糖异常和体重人群，当IFG的FBG切点>5.60 mmol/L时，可能会建立更准确的血糖异常诊断和结果。
