Zhang Meng-Hui, Wang Han, Wang Hong-Gang, Wen Xin, Yang Xiao-Zhong
Department of Gastroenterology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, China.
World J Clin Cases. 2021 Jan 16;9(2):334-343. doi: 10.12998/wjcc.v9.i2.334.
The inverse association between systemic immune-inflammation index (SII) and overall survival in tumors has been studied.
To evaluate the hematological indexes for assessing the activity of ulcerative colitis (UC).
In this case-control study, 172 UC patients and healthy participants were included. Comparisons were made among groups of white blood cells, hemoglobin, platelets, neutrophils, lymphocytes, monocytes, SII, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR). The relationship with hematological inflammation was verified by Spearman correlation analyses. The efficiency of SII, NLR, and PLR for distinguishing between UC and severe disease status was assessed by the receiver operator curve and logistic regression analyses.
The values of SII, NLR, and PLR were higher in UC patients than in controls ( < 0.001) and were positively correlated with the Mayo endoscopic score, extent, Degree of Ulcerative Colitis Burden of Luminal Inflammation (DUBLIN) score, and Ulcerative Colitis Endoscopic Index of Severity (UCEIS). The cut-off NLR value of 562.22 predicted UC with a sensitivity of 79.65% and a specificity of 76.16%. Logistic regression analysis revealed that patients with SII and NLR levels above the median had a significantly higher risk of UC ( < 0.05). Risk factors independently associated with DUBLIN ≥ 3 included SII ≥ 1776.80 [odds ratio (OR) = 11.53, = 0.027] and NLR value of 2.67-4.23 (OR = 2.96, = 0.047) on multivariate analysis. Compared with the first quartile, SII ≥ 1776.80 was an independent predictor of UCEIS ≥ 5 (OR = 18.46, = 0.012).
SII has a certain value in confirming UC and identifying its activity.
系统性免疫炎症指数（SII）与肿瘤总生存期之间的负相关关系已得到研究。
评估用于评估溃疡性结肠炎（UC）活动度的血液学指标。
在这项病例对照研究中，纳入了172例UC患者和健康参与者。对白细胞、血红蛋白、血小板、中性粒细胞、淋巴细胞、单核细胞、SII、中性粒细胞与淋巴细胞比值（NLR）以及血小板与淋巴细胞比值（PLR）等组间进行比较。通过Spearman相关性分析验证与血液学炎症的关系。通过受试者工作特征曲线和逻辑回归分析评估SII、NLR和PLR区分UC与疾病严重程度的效能。
UC患者的SII、NLR和PLR值高于对照组（<0.001），且与梅奥内镜评分、病变范围、溃疡性结肠炎肠腔炎症负担程度（DUBLIN）评分以及溃疡性结肠炎内镜严重程度指数（UCEIS）呈正相关。NLR的截断值为562.22时，预测UC的灵敏度为79.65%，特异度为76.16%。逻辑回归分析显示，SII和NLR水平高于中位数的患者患UC的风险显著更高（<0.05）。多因素分析中，与DUBLIN≥3独立相关的危险因素包括SII≥1776.80 [比值比（OR）=11.53，=0.027]和NLR值为2.67 - 4.23（OR = 2.96，=0.047）。与第一四分位数相比，SII≥1776.80是UCEIS≥5的独立预测因素（OR = 18.46，=0.012）。
SII在确诊UC及其活动度方面具有一定价值。
