Laboratory of Peptide Research and Development, School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad & Tobago, West Indies.
Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico, USA.
Arch Pharm (Weinheim). 2021 Apr;354(4):e2000446. doi: 10.1002/ardp.202000446. Epub 2021 Feb 1.
Cyclopolypeptides are among the most predominant biomolecules in nature, especially those derived from plant seeds. This category of compounds has gained extraordinary attention due to remarkable variety of structures and valuable biofunctions. These congeners display enormous variation in terms of both structure and function and are the most significant biomolecules due to their widespread bioproperties. The estrogenic activity, immunosuppressive activity, cytotoxicity, vasorelaxant activity, and other properties possessed by cyclic peptides from seeds of plants make these congeners attractive leads for the drug discovery process. The current study covers the important structural features, structure-activity relationship, synthesis methods, and bioproperties of plant seeds-originated bioactive peptides from Vaccaria segetalis, Linum usitatissimum, and Goniothalamus leiocarpus, which may prove vital for the development of novel therapeutics based on a peptide skeleton.
环肽是自然界中最主要的生物分子之一，特别是那些来源于植物种子的环肽。由于其结构和生物功能的多样性，这类化合物引起了人们的极大关注。这些同系物在结构和功能上都有很大的差异，是最重要的生物分子，因为它们具有广泛的生物特性。植物种子中环肽具有雌激素活性、免疫抑制活性、细胞毒性、血管舒张活性等特性，这使得这些同系物成为药物发现过程中极具吸引力的先导化合物。本研究综述了具有重要结构特征、构效关系、合成方法和生物活性的植物种子源生物活性肽，这些肽可能对基于肽骨架的新型治疗药物的开发具有重要意义。
