School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies.
Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, Medical Sciences Campus, San Juan, PR, 00936, USA.
Eur J Med Chem. 2021 Mar 15;214:113221. doi: 10.1016/j.ejmech.2021.113221. Epub 2021 Jan 23.
The Annona L. is one of the most significant genus of the Annonaceae family due to its widespread medicinal properties. This genus has a variety of active metabolites, including alkaloids, isoquinolines, peptides, acetogenins, lectins, volatile oils etc. Due to the constitution of cyclopeptides with an expanded spectrum of distinctive bioproperties, this genus is predominantly preferred over other species. The cytotoxicity, vasorelaxant activity, anti-inflammatory and other properties exhibited by cyclooligopeptides from seeds of Annona genus plants make these metabolites attractive leads for the drug discovery process. The present review covers the structural characteristics, structure activity relationship, synthesis strategies, pharmacological properties of plant seeds-originated bioactive peptides from Annona genus, which may be vital for the development of novel therapeutics based on peptide skeleton.
由于其广泛的药用特性，安农属（Annona L.）是番荔枝科（Annonaceae）中最重要的属之一。该属具有多种活性代谢物，包括生物碱、异喹啉、肽、乙酰氧基醇、凝集素、挥发油等。由于环肽的组成具有独特的生物特性谱，因此该属比其他物种更受青睐。来自番荔枝属植物种子的环寡肽具有细胞毒性、血管舒张活性、抗炎等特性，这使得这些代谢物成为药物发现过程中的有吸引力的先导物。本综述涵盖了植物种子来源的具有生物活性的肽的结构特征、结构活性关系、合成策略和番荔枝属植物的药理学特性，这对于基于肽骨架开发新型治疗药物可能至关重要。
