Department of Haematology and Oncology, University Children's Hospital Tuebingen, Hoppe-Seyler-Straße 1, 72076, Tuebingen, Germany.
Institute for Medical Virology, University Hospital Tuebingen, Elfriede-Aulhorn-Str. 6, 72076, Tuebingen, Germany.
BMC Infect Dis. 2021 Feb 1;21(1):133. doi: 10.1186/s12879-021-05791-8.
While our knowledge about COVID-19 in adults has rapidly increased, data on the course of disease and outcome in children with different comorbidities is still limited.
Prospective, observational study at a tertiary care children's hospital in southern Germany. Clinical and virology data from all paediatric patients admitted with SARS-CoV-2 infection at our hospital were prospectively assessed.
Between March and November 2020, 14 patients were admitted with COVID-19. One patient was admitted a second time with COVID-19 6 months after initial disease. Among seven patients with severe underlying comorbidities, three developed multisystem inflammatory syndrome (MIS-C), two were admitted to the paediatric intensive care unit. One patient needed invasive ventilation. Another patient died shortly after discharge of COVID-19-related complications.
While COVID-19 generally causes mild disease in children, severe respiratory illness and MIS-C occur, in some cases with fatal outcome. Children with underlying diseases might be at special risk for severe disease.
尽管我们对成人 COVID-19 的了解迅速增加，但关于患有不同合并症的儿童疾病过程和结局的数据仍然有限。
在德国南部的一家三级儿童保健医院进行前瞻性观察研究。对我院收治的所有 SARS-CoV-2 感染的儿科患者的临床和病毒学数据进行前瞻性评估。
2020 年 3 月至 11 月期间，有 14 名患者因 COVID-19 入院。一名患者在初次发病后 6 个月因 COVID-19 再次入院。在 7 名患有严重基础合并症的患者中，有 3 名患者发生了多系统炎症综合征（MIS-C），有 2 名患者入住儿科重症监护病房。一名患者需要有创通气。另一名患者在 COVID-19 相关并发症出院后不久死亡。
虽然 COVID-19 通常在儿童中引起轻症，但也会出现严重的呼吸道疾病和 MIS-C，在某些情况下会导致致命后果。患有基础疾病的儿童可能有发生重症的特殊风险。
