1Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary.
2Department of Biochemistry, Semmelweis University, Budapest, Hungary.
Acta Microbiol Immunol Hung. 2021 Jan 29;68(1):1-6. doi: 10.1556/030.2021.01366.
The increasingly wide use of next-generation sequencing technologies has revolutionised our knowledge of microbial environments associated with human skin, gastrointestinal tract and blood. The collective set of microorganisms influences metabolic processes, affects immune responses, and so directly or indirectly modulates disease. Rosacea is a skin condition of abnormal inflammation and vascular dysfunction, and its progression is affected by Demodex mites on the skin surface. When looking into the effects influencing development of rosacea, it is not only the skin microbiome change that needs to be considered. Changes in the intestinal microbiome and their circulating metabolites, as well as changes in the blood microbiome also affect the progression of rosacea. Recent research has confirmed the increased presence of bacterial genera like Acidaminococcus and Megasphera in the intestinal microbiome and Rheinheimera and Sphingobium in the blood microbiome of rosacea patients. In this review we discuss our current knowledge of the interactions between the immune system and the skin, gut and blood microbiome, with particular attention to rosacea diagnostic opportunities.
随着下一代测序技术的广泛应用，我们对与人类皮肤、胃肠道和血液相关的微生物环境的认识发生了革命性的变化。这些微生物的集合影响着代谢过程，影响着免疫反应，从而直接或间接地调节着疾病。酒渣鼻是一种异常炎症和血管功能障碍的皮肤状况，其进展受到皮肤表面的螨虫的影响。在研究影响酒渣鼻发展的因素时，不仅需要考虑皮肤微生物组的变化。肠道微生物组及其循环代谢物的变化，以及血液微生物组的变化也会影响酒渣鼻的进展。最近的研究证实，在酒渣鼻患者的肠道微生物组中，酸性氨基酸球菌属和巨球形菌属的存在增加，而血液微生物组中莱茵海默菌属和鞘氨醇单胞菌属的存在也增加。在这篇综述中，我们讨论了我们目前对免疫系统与皮肤、肠道和血液微生物组之间相互作用的认识，特别关注酒渣鼻的诊断机会。
