Department of Dermatology, Sichuan Provincial Peoples Hospital, University of Electronic. Science and Technology of China, Chengdu, China.
Healthcare-associated Infection Control Center, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Front Immunol. 2024 Aug 23;15:1419005. doi: 10.3389/fimmu.2024.1419005. eCollection 2024.
Rosacea has a high incidence, significantly impacts quality of life, and lacks sufficient diagnostic techniques. This study aimed to investigate the feasibility of laser speckle contrast imaging (LSCI) for measuring facial blood perfusion in patients with rosacea and to identify differences in blood flow among various facial regions associated with different rosacea subtypes.
From June to December 2023, 45 patients were recruited, with 9 excluded, leaving 36 subjects: 12 with erythematotelangiectatic rosacea (ETR), 12 with papulopustular rosacea (PPR), and 12 healthy controls. The Think View multispectral imaging analyzer assessed inflammation via gray reading values across the full face and five facial areas: forehead, nose, cheeks, and chin. LSCI measured and analyzed blood perfusion in the same areas. Plasma biomarkers interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α (TNF-α) were tested in different groups.
Both ETR and PPR groups showed increased average blood perfusion and facial inflammation intensity by gray values compared to controls, with statistically significant differences. Average blood perfusion of ETR and PPR groups showed increased values in the forehead, cheeks, and nose, compared to controls, and the values in the cheeks were statistically different between ETR and PPR. The facial inflammation intensity of the ETR group showed increased values in the forehead and cheeks, and the PPR group showed increased gray values in the forehead, cheeks, nose, and chin compared to controls, and the values for the cheeks, nose, and chin were statistically significantly different between ETR and PPR. Plasma biomarkers IL-6, IL-1β, and TNF-α were significantly elevated in both ETR and PPR groups compared to controls.
LSCI is a valuable, non-invasive tool for assessing blood flow dynamics in rosacea, providing a data foundation for clinical research. Different rosacea subtypes exhibit distinct lesion distribution and blood flow patterns, and both ETR and PPR could affect all facial areas, particularly the cheeks in ETR and the forehead, nose, and chin in PPR.
酒渣鼻发病率高，显著影响生活质量，且缺乏充分的诊断技术。本研究旨在探讨激光散斑对比成像（LSCI）测量酒渣鼻患者面部血液灌注的可行性，并确定与不同酒渣鼻亚型相关的不同面部区域的血流差异。
2023 年 6 月至 12 月，共招募 45 例患者，其中 9 例被排除，最终纳入 36 例患者：12 例红斑毛细血管扩张型酒渣鼻（ETR），12 例丘疹脓疱型酒渣鼻（PPR），12 例健康对照。Think View 多光谱成像分析仪通过全脸和五个面部区域（额部、鼻部、颊部和颏部）的灰度值评估炎症。LSCI 测量并分析了相同区域的血液灌注。不同组检测了白细胞介素 6（IL-6）、白细胞介素 1β（IL-1β）和肿瘤坏死因子-α（TNF-α）等血浆生物标志物。
与对照组相比，ETR 和 PPR 组的平均血液灌注和面部炎症强度的灰度值均增加，且差异具有统计学意义。与对照组相比，ETR 和 PPR 组的额部、颊部和鼻部的平均血液灌注值增加，而 ETR 和 PPR 组之间的颊部血液灌注值差异具有统计学意义。与对照组相比，ETR 组的额部和颊部的面部炎症强度灰度值增加，PPR 组的额部、颊部、鼻部和颏部的灰度值增加，而 ETR 和 PPR 组之间的颊部、鼻部和颏部的灰度值差异具有统计学意义。与对照组相比，ETR 和 PPR 组的白细胞介素 6（IL-6）、白细胞介素 1β（IL-1β）和肿瘤坏死因子-α（TNF-α）等血浆生物标志物水平均显著升高。
LSCI 是评估酒渣鼻血流动力学的一种有价值的非侵入性工具，为临床研究提供了数据基础。不同的酒渣鼻亚型表现出不同的病变分布和血流模式，ETR 和 PPR 均可影响所有面部区域，尤其是 ETR 的颊部和 PPR 的额部、鼻部和颏部。
