Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Department of Biochemistry, Ewha Womans University, School of Medicine, Seoul, South Korea.
Exp Dermatol. 2018 Jan;27(1):37-42. doi: 10.1111/exd.13398. Epub 2017 Aug 15.
Rosacea is a chronic inflammatory dermatosis affecting the face and eyes. An association between systemic comorbidities and rosacea has been reported, but the link to enteral microbiota is uncertain. We aimed to investigate the link between rosacea and enteral microbiota. A cross-sectional study was performed in a sample of Korean women who participated in a health check-up programme at the Kangbuk Samsung Hospital Health Screening Center between 23 June 2014 and 5 September 2014. The gut microbiome was evaluated by 16S rRNA gene and metagenome sequence analyses. A total of 12 rosacea patients and 251 controls were enrolled. We identified links between rosacea and several changes in gut microbiota: reduced abundance of Peptococcaceae family unknown genus, Methanobrevibacter (genus), Slackia (genus), Coprobacillus (genus), Citrobacter (genus), and Desulfovibrio (genus), and increased abundance of Acidaminococcus (genus), Megasphaera (genus), and Lactobacillales order unknown family unknown genus. A link between rosacea and enteral microbiota was observed in this metagenomic study. A large and elaborate study is needed to confirm these findings and to elucidate the mechanisms involved.
酒渣鼻是一种影响面部和眼部的慢性炎症性皮肤病。已有报道称系统性合并症与酒渣鼻之间存在关联，但与肠道微生物群的联系尚不确定。我们旨在研究酒渣鼻与肠道微生物群之间的联系。本研究为横断面研究，纳入了 2014 年 6 月 23 日至 9 月 5 日期间在 Kangbuk Samsung 医院健康筛查中心参加健康检查计划的韩国女性。通过 16S rRNA 基因和宏基因组序列分析评估肠道微生物组。共纳入 12 名酒渣鼻患者和 251 名对照。我们确定了酒渣鼻与肠道微生物群的几种变化之间的联系：Peptococcaceae 科未知属、Methanobrevibacter（属）、Slackia（属）、Coprobacillus（属）、Citrobacter（属）和 Desulfovibrio（属）丰度降低，以及 Acidaminococcus（属）、Megasphaera（属）和乳杆菌目未知属丰度增加。在这项宏基因组研究中观察到酒渣鼻与肠道微生物群之间存在联系。需要进行更大规模和更精细的研究来证实这些发现并阐明相关机制。
