Mason Alexander F, van Hest Jan C M
Department of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands.
Department of Chemical Engineering and Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands.
Emerg Top Life Sci. 2019 Nov 11;3(5):567-571. doi: 10.1042/ETLS20190094.
Cells, the discrete living systems that comprise all life on Earth, are a boundless source of inspiration and motivation for many researchers in the natural sciences. In the field of bottom-up synthetic cells, researchers seek to create multifaceted, self-assembled, chemical systems that mimic the properties and behaviours of natural life. In this perspective, we will describe the relatively recent application of complex coacervates to synthetic cells, and how they have been used to model an expanding range of biologically relevant phenomena. Furthermore, we will explore the unique advantages and disadvantages of coacervate-based synthetic cells, and their potential impact on the field in the years to come.
细胞是构成地球上所有生命的离散生命系统，对许多自然科学领域的研究人员来说，它们是灵感和动力的无尽源泉。在自下而上合成细胞领域，研究人员致力于创建多方面的、自组装的化学系统，以模拟自然生命的特性和行为。从这个角度出发，我们将描述复杂凝聚物在合成细胞中的相对近期的应用，以及它们如何被用于模拟越来越多的与生物学相关的现象。此外，我们将探讨基于凝聚物的合成细胞的独特优缺点，以及它们在未来几年对该领域的潜在影响。
