Soltani Saber, Zakeri Armin, Tabibzadeh Alireza, Zakeri Amir Mohammad, Zandi Milad, Siavoshi Saba, Seifpour Saba, Farahani Abbas
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran.
Mol Biol Rep. 2021 Feb;48(2):1801-1817. doi: 10.1007/s11033-021-06152-z. Epub 2021 Feb 1.
Previous literature supports the variations in microRNAs expression levels among lymphoma patients due to EBV infection. These alterations can be observed in both EBV-encoded-microRNAs and EBV-induced cellular microRNAs. Moreover, changes in the microRNA profile could be significant in disease progression. This study aimed to assess published literature to obtain a microRNA profile for both EBV-encoded microRNAs and EBV-induced cellular microRNAs among lymphoma patients. We searched common available electronic databases by using relevant keywords. The result demonstrated that EBV infection could alter the microRNA expression levels among lymphoma patients. In Burkitt lymphoma, hsa-miR197 and miR510 were most frequently assessed human micro RNAs. Also, miR-BART6-3P and miR-BART17-5P were the most frequent viral micro RNAs in Burkitt lymphoma. Other human important micro RNAs were hsa-miR155 (in Diffuse large B cell lymphoma (DLBCL)), hsa-miR145 (in Nasal natural killer T cell lymphoma (NNKTCL)), miR-96, miR-128a, miR-128b, miR-129, and miR-205 (in Classic Hodgkin lymphoma (CHL)), miR-21, miR-142-3P, miR-126, miR-451 and miR-494-3P (in Nasal natural killer cell lymphoma (NNKCL)). Also, viral assessed micro RNAs were miR-BART1-5P (in DLBCL and NNKTCL), miR-BART-5 (in CHL), and EBV-miR-BART20-5P (in NNKCL). In conclusion, it could be suggested that EBV-encoded-microRNAs and EBV-induced cellular-microRNAs can be utilized as helpful factors for different types of lymphoma diagnoses or prognostic factors. Moreover, the mentioned microRNAs can also be promising therapeutic targets and can be used to modulate the oncogenes.
以往文献支持淋巴瘤患者中由于EBV感染导致微小RNA表达水平存在差异。这些改变在EBV编码的微小RNA和EBV诱导的细胞微小RNA中均可观察到。此外，微小RNA谱的变化在疾病进展中可能具有重要意义。本研究旨在评估已发表的文献，以获得淋巴瘤患者中EBV编码的微小RNA和EBV诱导的细胞微小RNA的微小RNA谱。我们使用相关关键词搜索了常见的电子数据库。结果表明，EBV感染可改变淋巴瘤患者的微小RNA表达水平。在伯基特淋巴瘤中，hsa-miR197和miR510是最常被评估的人类微小RNA。此外，miR-BART6-3P和miR-BART17-5P是伯基特淋巴瘤中最常见的病毒微小RNA。其他重要的人类微小RNA包括hsa-miR155（在弥漫性大B细胞淋巴瘤（DLBCL）中）、hsa-miR145（在鼻型自然杀伤T细胞淋巴瘤（NNKTCL）中）、miR-96、miR-128a、miR-128b、miR-129和miR-205（在经典型霍奇金淋巴瘤（CHL）中）、miR-21、miR-142-3P、miR-126、miR-451和miR-494-3P（在鼻型自然杀伤细胞淋巴瘤（NNKCL）中）。此外，被评估的病毒微小RNA包括miR-BART1-5P（在DLBCL和NNKTCL中）、miR-BART-5（在CHL中）和EBV-miR-BART20-5P（在NNKCL中）。总之，可以认为EBV编码的微小RNA和EBV诱导的细胞微小RNA可作为不同类型淋巴瘤诊断的有用因素或预后因素。此外，上述微小RNA也可能是有前景的治疗靶点，可用于调节癌基因。
