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古菌酪氨酸重组酶。

Archaeal tyrosine recombinases.

机构信息

Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.

出版信息

FEMS Microbiol Rev. 2021 Aug 17;45(4). doi: 10.1093/femsre/fuab004.

DOI:10.1093/femsre/fuab004
PMID:33524101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8371274/
Abstract

The integration of mobile genetic elements into their host chromosome influences the immediate fate of cellular organisms and gradually shapes their evolution. Site-specific recombinases catalyzing this integration have been extensively characterized both in bacteria and eukarya. More recently, a number of reports provided the in-depth characterization of archaeal tyrosine recombinases and highlighted new particular features not observed in the other two domains. In addition to being active in extreme environments, archaeal integrases catalyze reactions beyond site-specific recombination. Some of these integrases can catalyze low-sequence specificity recombination reactions with the same outcome as homologous recombination events generating deep rearrangements of their host genome. A large proportion of archaeal integrases are termed suicidal due to the presence of a specific recombination target within their own gene. The paradoxical maintenance of integrases that disrupt their gene upon integration implies novel mechanisms for their evolution. In this review, we assess the diversity of the archaeal tyrosine recombinases using a phylogenomic analysis based on an exhaustive similarity network. We outline the biochemical, ecological and evolutionary properties of these enzymes in the context of the families we identified and emphasize similarities and differences between archaeal recombinases and their bacterial and eukaryal counterparts.

摘要

移动遗传元件整合到宿主染色体中会影响细胞生物的即时命运，并逐渐塑造其进化。催化这种整合的位点特异性重组酶在细菌和真核生物中都得到了广泛的研究。最近，一些报告深入研究了古菌酪氨酸重组酶，并强调了在其他两个领域中未观察到的新特征。除了在极端环境中活跃外，古菌整合酶还催化超越位点特异性重组的反应。其中一些整合酶可以催化低序列特异性重组反应，其结果与同源重组事件相同，从而导致宿主基因组的深度重排。由于其自身基因内存在特定的重组靶标，大量古菌整合酶被称为自杀性的。在整合后破坏其基因的整合酶的悖论性维持意味着它们进化的新机制。在这篇综述中，我们使用基于详尽相似性网络的系统基因组学分析来评估古菌酪氨酸重组酶的多样性。我们概述了这些酶在我们确定的家族中的生化、生态和进化特性，并强调了古菌重组酶与细菌和真核生物重组酶之间的相似性和差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23bb/8371274/20a23be210f7/fuab004fig13.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23bb/8371274/7944d5f4de4b/fuab004fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23bb/8371274/322c5c987c1d/fuab004fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23bb/8371274/81e1043d09ad/fuab004fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23bb/8371274/0f4eb8e98448/fuab004fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23bb/8371274/6ab0613fd1ab/fuab004fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23bb/8371274/2879a58b3161/fuab004fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23bb/8371274/20a23be210f7/fuab004fig13.jpg

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