Hsiao Fu-Jung, Chen Wei-Ta, Wang Yen-Feng, Chen Shih-Pin, Lai Kuan-Lin, Liu Hung-Yu, Pan Li-Ling Hope, Wang Shuu-Jiun
Brain Research Center, National Yang-Ming University, Taipei 112, Taiwan.
School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.
Brain Sci. 2021 Jan 28;11(2):166. doi: 10.3390/brainsci11020166.
Sensory gating, a habituation-related but more basic protective mechanism against brain sensory overload, is altered in patients with migraine and linked to headache severity. This study investigated whether somatosensory (SI) gating responses determined 3-months treatment outcomes in patients with episodic migraine (EM) and chronic migraine (CM). A 306-channel magnetoencephalography (MEG) with paired-pulse stimulation paradigm was used to record their neuromagnetic responses. To calculate the peak amplitude and latency and compute the gating ratios (second vs. first amplitude), the first and second responses to the paired stimuli from the primary somatosensory cortex were obtained. All patients were assigned to subgroups labeled good or poor according to their headache frequency at baseline compared with at the third month of treatment. The gating ratio in the CM group ( = 37) was significantly different between those identified as good and poor ( = 0.009). In the EM group ( = 30), the latency in the second response differed by treatment outcomes ( = 0.007). In the receiver operating characteristic analysis, the areas under the curve for the CM and EM groups were 0.737 and 0.761, respectively. Somatosensory gating responses were associated with treatment outcomes in patients with migraine; future studies with large patient samples are warranted.
感觉门控是一种与习惯化相关但更为基本的防止大脑感觉过载的保护机制，在偏头痛患者中会发生改变，且与头痛严重程度相关。本研究调查了体感（SI）门控反应是否能决定发作性偏头痛（EM）和慢性偏头痛（CM）患者3个月的治疗结果。采用具有配对脉冲刺激范式的306通道脑磁图（MEG）记录他们的神经磁反应。为了计算峰值振幅和潜伏期并计算门控比率（第二次与第一次振幅），获取了来自初级体感皮层的配对刺激的第一次和第二次反应。根据基线时与治疗第三个月时的头痛频率，将所有患者分为反应良好或反应不佳的亚组。在CM组（n = 37）中，被认定为反应良好和反应不佳的患者之间的门控比率有显著差异（P = 0.009）。在EM组（n = 30）中，第二次反应的潜伏期因治疗结果而异（P = 0.007）。在受试者工作特征分析中，CM组和EM组的曲线下面积分别为0.737和0.761。体感门控反应与偏头痛患者的治疗结果相关；有必要对大量患者样本进行进一步研究。
