Laboratory of Functional Genomics and Proteomics, National Centre for Biomolecular Research, Faculty of Science, Masaryk University, CZ-61137 Brno, Czech Republic.
Chromatin Molecular Complexes, Mendel Centre for Plant Genomics and Proteomics, Central European Institute of Technology, Masaryk University, CZ-62500 Brno, Czech Republic.
Int J Mol Sci. 2021 Jan 28;22(3):1302. doi: 10.3390/ijms22031302.
Genes encoding ribosomal RNA (rDNA) are essential for cell survival and are particularly sensitive to factors leading to genomic instability. Their repetitive character makes them prone to inappropriate recombinational events arising from collision of transcriptional and replication machineries, resulting in unstable rDNA copy numbers. In this review, we summarize current knowledge on the structure and organization of rDNA, its role in sensing changes in the genome, and its linkage to aging. We also review recent findings on the main factors involved in chromatin assembly and DNA repair in the maintenance of rDNA stability in the model plants and the moss , providing a view across the plant evolutionary tree.
基因编码核糖体 RNA(rDNA)对于细胞存活至关重要，并且特别容易受到导致基因组不稳定的因素的影响。它们的重复特性使它们容易受到转录和复制机制碰撞引起的不当重组事件的影响，从而导致 rDNA 拷贝数不稳定。在这篇综述中，我们总结了 rDNA 的结构和组织、其在感知基因组变化中的作用以及与衰老的联系的最新知识。我们还回顾了模型植物和苔藓中参与染色质组装和 DNA 修复以维持 rDNA 稳定性的主要因素的最新发现，提供了跨越植物进化树的观点。
