从中分离鉴定出新的prenylated acetophenone 衍生物。

Isolation and identification of new prenylated acetophenone derivatives from .

机构信息

a Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou , People's Republic of China.

b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou , People's Republic of China.

出版信息

Nat Prod Res. 2019 Aug;33(15):2230-2235. doi: 10.1080/14786419.2018.1490902. Epub 2018 Oct 31.

DOI:10.1080/14786419.2018.1490902

PMID:30379092

Abstract

Three new prenylated acetophenone derivatives, acronyculatin P (), acronyculatin Q (), and acronyculatin R () were isolated from the leaves of . Their structures were identified by extensive analyses of spectroscopic data (IR, UV, ESI-HRMS, 1D and 2D NMR) and comparison with the literatures. In addition, the cytotoxic activity against MCF-7 cells of the compounds were evaluated by the MTT assay and the IC values were 56.8, 40.4 and 69.1 μM, respectively.

摘要

从 Acronychia pedunculata 的叶子中分离得到了三种新的苯乙酮类化合物，分别为 acronyculatin P ()、acronyculatin Q () 和 acronyculatin R ()。通过对光谱数据（IR、UV、ESI-HRMS、1D 和 2D NMR）的广泛分析以及与文献的比较，确定了它们的结构。此外，通过 MTT 法评估了化合物对 MCF-7 细胞的细胞毒性活性，IC 值分别为 56.8、40.4 和 69.1 μM。