Department of Vitreoretina and Uveitis, LV Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India
Department of Vitreoretina and Uveitis, LV Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India.
BMJ Case Rep. 2021 Feb 1;14(2):e238490. doi: 10.1136/bcr-2020-238490.
A male infant, born preterm at 32 weeks of gestation, was referred at 36-week postmenstrual age for retinopathy of prematurity (ROP) screening. He had nystagmus, generalised hypopigmentation of skin, hair and eyes with preaxial polydactyly. The fundus was depigmented with prominently visible choroidal vessels. The retinal vessels were dilated, tortuous at zone 1. There was presence of arcading, shunting of vessels with presence of vitreous haemorrhage in the left eye. A diagnosis of aggressive posterior retinopathy of prematurity (APROP) in association with oculocutaneous albinism (OCA) was made.Half-dose intravitreal bevacizumab was used to treat the vascular condition. After 2 weeks, there was complete regression of APROP with a completely mature retina observed at 4 months post-treatment. Herein, we describe the role of red-free light for screening ROP in infants with OCA; challenges in the management of ROP with laser photocoagulation compared with intravitreal anti-vascular endothelial growth factor therapy.
一名男性婴儿，胎龄 32 周早产，在 36 周龄时因早产儿视网膜病变（ROP）筛查而转来。他有眼球震颤、全身皮肤、毛发和眼睛色素减退，伴有前轴多指。眼底色素脱失，脉络膜血管明显可见。视网膜血管扩张，在 1 区呈扭曲状。存在弓状吻合、血管分流，左眼有玻璃体出血。诊断为伴有眼皮肤白化病（OCA）的侵袭性后部早产儿视网膜病变（APROP）。采用半剂量玻璃体内注射贝伐单抗治疗血管病变。2 周后，APROP 完全消退，治疗后 4 个月观察到完全成熟的视网膜。本文描述了在 OCA 婴儿中使用无赤光筛查 ROP 的作用；与玻璃体内抗血管内皮生长因子治疗相比，激光光凝治疗 ROP 的管理挑战。
