Suppr超能文献

种族差异对主动脉瓣狭窄的治疗:经导管主动脉瓣置换术是否缩小了差距?

Racial disparities in the treatment of aortic stenosis: Has transcatheter aortic valve replacement bridged the gap?

机构信息

Division of Cardiology, Department of Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

Department of Cardiology, Robert Wood Johnson University Hospital, New Brunswick, New Jersey.

出版信息

Catheter Cardiovasc Interv. 2021 Jul 1;98(1):148-156. doi: 10.1002/ccd.29487. Epub 2021 Feb 1.

Abstract

BACKGROUND

Racial disparities in outcomes and utilization of surgical aortic valve replacement (SAVR) for the treatment of severe aortic stenosis (AS) is well known. While transcatheter aortic valve replacement (TAVR) has become more widespread, its impact on racial disparities remains unclear.

OBJECTIVES

Our goal was to assess the utilization of SAVR and TAVR and their clinical outcomes among various racial groups.

METHODS

The National Inpatient database (2009-2015) was used to study the racial distribution of admissions for SAVR and TAVR, and their impact on inpatient outcomes. Survey estimation commands were used to determine weighted national estimates.

RESULTS

There were 3,445,267; 294,108; and 52,913 inpatient visits for AS, SAVR, and TAVR, respectively. SAVR visits were 86% White, 3.8% Black, 5.5% Hispanic, 1.2% Asian/Pacific Islander (A/PI), 0.4% Native American (NA), and 2.9%; TAVR were 87.7% White, 3.7% Black, 3.8% Hispanic, 1.0% A/PI, 0.2% NA, and 3.5% Other while AS visits were 83.7% White, 6.7% Black, 5.3% Hispanic, 1.7% A/PI, 0.4% NA, and 2.2% Other. Racial minorities generally had more co-morbidities compared with Whites. After SAVR, Black patients had a higher unadjusted inpatient mortality than Whites, however, there was no difference after adjustment for other variables. A/PI were more likely to require a permanent pacemaker after SAVR. Need for blood transfusion was significantly higher among the minorities compared with Whites, except for NA, but there were no racial differences in stroke rates. There was no difference in inpatient mortality, pacemaker implantation, stroke, and bleeding after TAVR, but acute kidney injury occurred more often in Hispanics, A/PI, and "others" compared with Whites.

CONCLUSIONS

Racial disparities in the treatment of AS continues in the contemporary era; however it was found that TAVR resulted in comparable inpatient outcomes, despite higher comorbidities, and adverse socioeconomic factors in minorities.

摘要

背景

种族差异在接受主动脉瓣置换术(SAVR)治疗严重主动脉瓣狭窄(AS)的效果和利用方面是众所周知的。虽然经导管主动脉瓣置换术(TAVR)已经得到了更广泛的应用,但它对种族差异的影响仍不清楚。

目的

我们的目标是评估不同种族群体接受 SAVR 和 TAVR 的情况及其临床结局。

方法

使用国家住院患者数据库(2009-2015 年)研究 SAVR 和 TAVR 的住院分布情况及其对住院结局的影响。使用调查估计命令来确定全国加权估计值。

结果

AS、SAVR 和 TAVR 的住院患者分别为 3445267 例、294108 例和 52913 例。SAVR 患者中 86%为白人,3.8%为黑人,5.5%为西班牙裔,1.2%为亚裔/太平洋岛民(A/PI),0.4%为美洲原住民(NA),2.9%为其他种族;TAVR 患者中 87.7%为白人,3.7%为黑人,3.8%为西班牙裔,1.0%为 A/PI,0.2%为 NA,3.5%为其他种族,而 AS 患者中 83.7%为白人,6.7%为黑人,5.3%为西班牙裔,1.7%为 A/PI,0.4%为 NA,2.2%为其他种族。与白人相比,少数民族患者通常合并更多的疾病。在接受 SAVR 治疗后,黑人患者的未调整住院死亡率高于白人,但在调整其他变量后无差异。A/PI 患者在接受 SAVR 治疗后更有可能需要永久性起搏器。与白人相比,少数民族患者需要输血的情况明显更高,除了 NA 族裔,但在中风发生率方面没有种族差异。在接受 TAVR 治疗后,住院死亡率、起搏器植入、中风和出血没有差异,但与白人相比,西班牙裔、A/PI 和“其他”人群更易发生急性肾损伤。

结论

在当代,AS 的治疗中仍然存在种族差异;然而,尽管少数民族患者合并更多的疾病和不利的社会经济因素,但 TAVR 治疗结果相当。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验