Plastic and Reconstructive Surgery - Burn Unit, Centro Hospitalar Universitário de São João, Porto, Portugal.
Anesthesiology - Burn Unit, Centro Hospitalar Universitário de São João, Porto, Portugal.
J Burn Care Res. 2021 Aug 4;42(4):829-831. doi: 10.1093/jbcr/irab023.
Severe cutaneous adverse drug reactions are uncommon but potentially critical clinical situations demanding prompt diagnosis and treatment. We report a rare and severe case of terbinafine-induced acute generalized pustulosis. The patient was directly referred to a Burn Unit where she underwent diagnostic confirmation, systemic supportive care, and wound care treatments. Clinical and histopathological differential diagnosis of severe cutaneous adverse drug reactions is fundamental due to their significantly different management and prognosis.
严重的药物不良反应并不常见，但却是潜在的危急临床情况，需要迅速诊断和治疗。我们报告了一例罕见且严重的特比萘芬诱导的急性泛发性脓疱病。患者被直接转诊至烧伤科，在那里进行了诊断确认、全身支持治疗和伤口护理治疗。由于严重药物不良反应的管理和预后显著不同，因此进行临床和组织病理学鉴别诊断至关重要。
