Hader W J, Elliot M, Ebers G C
Department of Clinical Neurological Sciences, University of Western Ontario, University Hospital, London, Canada.
Neurology. 1988 Apr;38(4):617-21. doi: 10.1212/wnl.38.4.617.
A case-controlled epidemiologic study of multiple sclerosis (MS) was carried out in London, Ontario, and its surrounding Middlesex County for the period 1974-1983. The prevalence rates for clinically definite/probable MS on January 1, 1984 were 94/100,000 for the city and 91/100,000 for the county. The estimated annual incidence rate for the decade 1974-83 was 3.4/100,000. The female-to-male sex ratio was 2.5:1. A familial history of MS was recorded in 14.4% of close relatives and a total of 17% when distant relatives are included. The MS group is predominantly of British (70%) and European (23%) origin. The urban-rural residence pattern analysis indicates no significant regional influence on the risk of developing MS.
1974年至1983年期间，在安大略省伦敦市及其周边的米德尔塞克斯县开展了一项多发性硬化症（MS）的病例对照流行病学研究。1984年1月1日，临床确诊/疑似MS的患病率在城市为94/10万，在该县为91/10万。1974 - 1983年这十年间的估计年发病率为3.4/10万。男女比例为2.5:1。14.4%的近亲有MS家族史，若包括远亲则总计为17%。MS组主要起源于英国（70%）和欧洲（23%）。城乡居住模式分析表明，地区因素对患MS风险无显著影响。
