应用美国癌症联合委员会/国际抗癌联盟第 8 版分期系统预测口腔舌鳞状细胞癌。
Predictive nomograms for oral tongue squamous cell carcinoma applying the American Joint Committee on Cancer/Union Internationale Contre le Cancer 8th edition staging system.
机构信息
Department of Head and Neck Oncology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, India.
IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
出版信息
Head Neck. 2021 Apr;43(4):1043-1055. doi: 10.1002/hed.26554. Epub 2021 Feb 2.
BACKGROUND
Nomograms applying the 8th edition of the TNM staging system aimed at predicting overall (OS), disease-specific (DSS), locoregional recurrence-free (LRRFS) and distant recurrence-free survivals (DRFS) for oral tongue squamous cell carcinoma (OTSCC) are still lacking.
METHODS
A training cohort of 438 patients with OTSCC was retrospectively enrolled from a single institution. An external validation set of 287 patients was retrieved from two independent institutions.
RESULTS
Internal validation of the multivariable models for OS, DSS, DRFS and LRRFS showed a good calibration and discrimination results with optimism-corrected c-indices of 0.74, 0.75, 0.77 and 0.70, respectively. The external validation confirmed the good performance of OS, DSS and DRFS models (c-index 0.73 and 0.77, and 0.73, respectively) and a fair performance of the LRRFS model (c-index 0.58).
CONCLUSIONS
The nomograms herein presented can be implemented as useful tools for prediction of OS, DSS, DRFS and LRRFS in OTSCC.
背景
目前仍缺乏适用于第八版 TNM 分期系统的列线图，以预测口腔舌鳞状细胞癌（OTSCC）的总生存（OS）、疾病特异性生存（DSS）、局部区域无复发生存（LRRFS）和远处无复发生存（DRFS）。
方法
本研究回顾性纳入了来自单一机构的 438 例 OTSCC 患者作为训练队列，并从另外两个独立的机构中提取了 287 例患者作为外部验证队列。
结果
多变量模型的内部验证结果显示，OS、DSS、DRFS 和 LRRFS 的校准和区分度均较好，经校正后的 C 指数分别为 0.74、0.75、0.77 和 0.70。外部验证结果也确认了 OS、DSS 和 DRFS 模型的良好表现（C 指数分别为 0.73、0.77 和 0.73），以及 LRRFS 模型的中等表现（C 指数为 0.58）。
结论
本研究建立的列线图可作为预测 OTSCC 患者 OS、DSS、DRFS 和 LRRFS 的有用工具。
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